Journal article
Vasopressin inhibits diuresis induced by water immersion in humans
Journal of applied physiology (1985), Vol.73(3), pp.932-936
09/01/1992
DOI: 10.1152/jappl.1992.73.3.932
PMID: 1400058
Abstract
We tested the hypothesis that 1-desamino-8-D-arginine vasopressin (DDAVP), a V2-receptor agonist, could inhibit the diuresis induced by water immersion in humans. Water and electrolyte excretion, plasma atrial natriuretic factor concentration, and plasma aldosterone concentration were measured initially and after 3 h of water immersion in 13 healthy sodium-replete men given either placebo or 20 micrograms of intranasal DDAVP. Guanosine 3′,5′-cyclic monophosphate and urea excretion and urine osmolality were also determined. DDAVP inhibited the diuresis induced by water immersion in men: 758 +/- 168 (SE) ml/3 h in the placebo group vs. 159 +/- 28 ml/3 h in the DDAVP group (P less than 0.05). After 3 h of water immersion, plasma atrial natriuretic factor concentrations were increased from 11 +/- 2 to 20 +/- 4 pg/ml in the placebo group and from 14 +/- 2 to 33 +/- 4 pg/ml in the DDAVP group (P less than 0.05). Plasma aldosterone concentrations were decreased from 98 +/- 18 to 45 +/- 6 pg/ml in the placebo group (P less than 0.05) and from 54 +/- 17 to 25 +/- 5 pg/ml in the DDAVP group (P less than 0.05). Despite these changes in aldosterone and atrial natriuretic factor concentrations, which should increase sodium excretion, DDAVP decreased the natriuresis induced by water immersion in humans: 56 +/- 8 meq Na+/3 h in the placebo group vs. 36 +/- 6 meq Na+/3 h in the DDAVP group (P less than 0.05). DDAVP may be used to prevent the diuresis associated with central redistribution of blood volumes that occur during water immersion.
Details
- Title: Subtitle
- Vasopressin inhibits diuresis induced by water immersion in humans
- Creators
- S Farrow - Wayne State University School of Medicine, Detroit, Michigan 48201G Banta - Wayne State University School of Medicine, Detroit, Michigan 48201S Schallhorn - Wayne State University School of Medicine, Detroit, Michigan 48201R May - Wayne State University School of Medicine, Detroit, Michigan 48201A Mers - Wayne State University School of Medicine, Detroit, Michigan 48201L Cadaret - Wayne State University School of Medicine, Detroit, Michigan 48201L Rydstedt - Wayne State University School of Medicine, Detroit, Michigan 48201W Lockette - Wayne State University School of Medicine, Detroit, Michigan 48201
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.73(3), pp.932-936
- DOI
- 10.1152/jappl.1992.73.3.932
- PMID
- 1400058
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 09/01/1992
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094607002771
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