Ventilator-associated pneumonia at a tertiary-care center in a developing country: incidence, microbiology, and susceptibility patterns of isolated microorganisms

Zeina A Kanafani; Layla Kara; Shady Hayek; Souha S Kanj

doi:10.1086/502151

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Ventilator-associated pneumonia at a tertiary-care center in a developing country: incidence, microbiology, and susceptibility patterns of isolated microorganisms

Journal article

Peer reviewed

Ventilator-associated pneumonia at a tertiary-care center in a developing country: incidence, microbiology, and susceptibility patterns of isolated microorganisms

Zeina A Kanafani, Layla Kara, Shady Hayek and Souha S Kanj

Infection control and hospital epidemiology, Vol.24(11), pp.864-869

11/01/2003

DOI: 10.1086/502151

PMID: 14649777

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Abstract

Ventilator-associated pneumonia (VAP) complicates the course of up to 24% of intubated patients. Data from the Middle East are scarce. The objective of this study was to evaluate the incidence, microbiology, and antimicrobial susceptibility patterns of isolated microorganisms in VAP in a developing country. Prospective observational cohort study. The American University of Beirut Medical Center, a tertiary-care center that serves as a major referral center for Lebanon and neighboring countries. All patients admitted to the intensive care and respiratory care units from March to September 2001, and who had been receiving mechanical ventilation for at least 48 hours, were included in the study. Results of samples submitted for culture were recorded and antimicrobial susceptibility testing of isolated pathogens was performed. Seventy patients were entered into the study. The incidence of VAP was 47%. Gram-negative bacilli accounted for 83% of all isolates. The most commonly identified organism was Acinetobacter anitratus, followed by Pseudomonas aeruginosa. Fifty percent of all gram-negative bacterial isolates were classified as antibiotic resistant. Compared with patients without VAP, patients with VAP remained intubated for a longer period and stayed in the intensive care unit longer. VAP was not associated with an increased mortality rate. Compared with other studies, the results from this referral center in Lebanon indicate a higher incidence of VAP and a high prevalence of resistant organisms. These data are relevant because they direct the choice of empiric antibiotic therapy for VAP.

Acinetobacter - drug effects

Acinetobacter - isolation & purification

Adult

Aged

Aged, 80 and over

Cohort Studies

Cross Infection - microbiology

Cross Infection - transmission

Developing Countries

Drug Resistance, Bacterial

Equipment Contamination

Female

Hospitals, University

Humans

Incidence

Intensive Care Units - statistics & numerical data

Klebsiella - drug effects

Klebsiella - isolation & purification

Lebanon - epidemiology

Male

Middle Aged

Pneumonia, Bacterial - drug therapy

Pneumonia, Bacterial - epidemiology

Pneumonia, Bacterial - microbiology

Pseudomonas aeruginosa - drug effects

Pseudomonas aeruginosa - isolation & purification

Sentinel Surveillance

Staphylococcus aureus - drug effects

Staphylococcus aureus - isolation & purification

Treatment Outcome

Ventilators, Mechanical - microbiology

Details

Title: Subtitle: Ventilator-associated pneumonia at a tertiary-care center in a developing country: incidence, microbiology, and susceptibility patterns of isolated microorganisms
Creators: Zeina A Kanafani - American University of Beirut Medical Center
Layla Kara - Lebanese American University
Shady Hayek - American University of Beirut Medical Center
Souha S Kanj
Resource Type: Journal article
Publication Details: Infection control and hospital epidemiology, Vol.24(11), pp.864-869
DOI: 10.1086/502151
PMID: 14649777
ISSN: 0899-823X
eISSN: 1559-6834
Language: English
Date published: 11/01/2003
Academic Unit: Surgery
Record Identifier: 9984701805902771

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