Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia

Melissa L Bates; De-Ann M Pillers; Mari Palta; Emily T Farrell; Marlowe W Eldridge

doi:10.1016/j.resp.2013.07.015

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Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia

Journal article

Peer reviewed

Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia

Melissa L Bates, De-Ann M Pillers, Mari Palta, Emily T Farrell and Marlowe W Eldridge

Respiratory physiology & neurobiology, Vol.189(2), pp.329-337

11/01/2013

DOI: 10.1016/j.resp.2013.07.015

PMCID: PMC3812402

PMID: 23886637

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https://www.ncbi.nlm.nih.gov/pmc/articles/3812402View

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Abstract

•Individuals with broncopulmonary dysplasia may experience impairments in ventilatory control.•These impairments extend beyond infancy, with ventilatory control abnormalities noted in childhood and adulthood.•Ventilatory control abnormalities become apparent when metabolic supply and demand are challenged (e.g.; hypoxia, sleep, and exercise).•Ventilatory control in bronchopulmonary dysplasia is an important area for future investigation, but investigators should take care to understand the limitations of particular human populations. Bronchopulmonary dysplasia (BPD), or chronic lung disease of prematurity, occurs in ∼30% of preterm infants (15,000 per year) and is associated with a clinical history of mechanical ventilation and/or high inspired oxygen at birth. Here, we describe changes in ventilatory control that exist in patients with BPD, including alterations in chemoreceptor function, respiratory muscle function, and suprapontine control. Because dysfunction in ventilatory control frequently revealed when O2 supply and CO2 elimination are challenged, we provide this information in the context of four important metabolic stressors: stresses: exercise, sleep, hypoxia, and lung disease, with a primary focus on studies of human infants, children, and adults. As a secondary goal, we also identify three key areas of future research and describe the benefits and challenges of longitudinal human studies using well-defined patient cohorts.

Bronchopulmonary dysplasia

Exercise

Hypoxia

Premature infant

Sleep

Ventilatory control

Details

Title: Subtitle: Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia
Creators: Melissa L Bates - University of Wisconsin–Madison
De-Ann M Pillers - University of Wisconsin–Madison
Mari Palta - University of Wisconsin–Madison
Emily T Farrell - University of Wisconsin–Madison
Marlowe W Eldridge - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Respiratory physiology & neurobiology, Vol.189(2), pp.329-337
DOI: 10.1016/j.resp.2013.07.015
PMID: 23886637
PMCID: PMC3812402
NLM abbreviation: Respir Physiol Neurobiol
ISSN: 1569-9048
eISSN: 1878-1519
Publisher: Elsevier B.V
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: 5R01HL086897, 5T32HL007654
Language: English
Date published: 11/01/2013
Academic Unit: Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984259639102771

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