Journal article
Ventilatory response to CO 2 in patients with epilepsy
Epilepsia (Copenhagen), Vol.60(3), pp.508-517
03/2019
DOI: 10.1111/epi.14660
PMCID: PMC6401234
PMID: 30756391
Abstract
Severe periictal respiratory depression is thought to be linked to risk of sudden unexpected death in epilepsy (SUDEP) but its determinants are largely unknown. Interindividual differences in the interictal ventilatory response to CO
(hypercapnic ventilatory response [HCVR] or central respiratory CO
chemosensitivity) may identify patients who are at increased risk for severe periictal hypoventilation. HCVR has not been studied previously in patients with epilepsy; therefore we evaluated a method to measure it at bedside in an epilepsy monitoring unit (EMU) and examined its relationship to postictal hypercapnia following generalized convulsive seizures (GCSs).
Interictal HCVR was measured by a respiratory gas analyzer using a modified rebreathing technique. Minute ventilation (V
), tidal volume, respiratory rate, end tidal (ET) CO
and O
were recorded continuously. Dyspnea during the test was assessed using a validated scale. The HCVR slope (ΔV
/ΔETCO
) for each subject was determined by linear regression. During the video-electroencephalography (EEG) study, subjects underwent continuous respiratory monitoring, including measurement of chest and abdominal movement, oronasal airflow, transcutaneous (tc) CO
, and capillary oxygen saturation (SPO
).
Sixty-eight subjects completed HCVR testing in 151 ± (standard deviation) 58 seconds, without any serious adverse events. HCVR slope ranged from -0.94 to 5.39 (median 1.71) L/min/mm Hg. HCVR slope correlated with the degree of unpleasantness and intensity of dyspnea and was inversely related to baseline ETCO
. Both the duration and magnitude of postictal tcCO
rise following GCSs were inversely correlated with HCVR slope.
Measurement of the HCVR is well tolerated and can be performed rapidly and safely at the bedside in the EMU. A subset of individuals has a very low sensitivity to CO
, and this group is more likely to have a prolonged increase in postictal CO
after GCS. Low interictal HCVR may increase the risk of severe respiratory depression and SUDEP after GCS and warrants further study.
Details
- Title: Subtitle
- Ventilatory response to CO 2 in patients with epilepsy
- Creators
- Rup K Sainju - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IowaDeidre N Dragon - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IowaHarold B Winnike - Institute for Clinical and Translational Science, University of Iowa Carver College of Medicine, Iowa City, IowaMarcus B Nashelsky - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IowaMark A Granner - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IowaBrian K Gehlbach - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IowaGeorge B Richerson - Veterans Affairs Medical Center, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Epilepsia (Copenhagen), Vol.60(3), pp.508-517
- DOI
- 10.1111/epi.14660
- PMID
- 30756391
- PMCID
- PMC6401234
- NLM abbreviation
- Epilepsia
- ISSN
- 0013-9580
- eISSN
- 1528-1167
- Publisher
- United States
- Grant note
- UL1TR002537 / NCATS NIH HHS U54TR001356 / National Institutes of Health CTSA program UL1 TR002537 / NCATS NIH HHS U54 TR001356 / NCATS NIH HHS Funding informationCitizens United for Research in Epilepsy - SUDEP award U01 NS090414 / NINDS NIH HHS
- Language
- English
- Date published
- 03/2019
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Clinical Research Unit; Epidemiology; Pathology; Iowa Neuroscience Institute; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020760702771
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