Journal article
Ventral lateral geniculate input to the medial pons is necessary for visual eyeblink conditioning in rats
Learning & memory (Cold Spring Harbor, N.Y.), Vol.17(2), pp.80-85
02/2010
DOI: 10.1101/lm.1572710
PMCID: PMC2825698
PMID: 20154353
Abstract
The conditioned stimulus (CS) pathway that is necessary for visual delay eyeblink conditioning was investigated in the current study. Rats were initially given eyeblink conditioning with stimulation of the ventral nucleus of the lateral geniculate (LGNv) as the CS followed by conditioning with light and tone CSs in separate training phases. Muscimol was infused into the medial pontine nuclei (MPN) after each training phase to examine conditioned response (CR) retention to each CS. The spread of muscimol infusions targeting the MPN was examined with fluorescent muscimol. Muscimol infusions into the MPN resulted in a severe impairment in retention of CRs with the LGNv stimulation and light CSs. A less severe impairment was observed with the tone CS. The results suggest that CS information from the LGNv and light CSs is relayed to the cerebellum through the MPN. Retrograde tracing with fluoro-gold (FG) showed that the LGNv and nucleus of the optic tract have ipsilateral projections to the MPN. Unilateral inputs to the MPN from the LGNv and nucleus of the optic tract may be part of the visual CS pathway that is necessary for visual eyeblink conditioning.
Details
- Title: Subtitle
- Ventral lateral geniculate input to the medial pons is necessary for visual eyeblink conditioning in rats
- Creators
- Hunter E Halverson - Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USAJohn H Freeman - Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), Vol.17(2), pp.80-85
- Publisher
- Cold Spring Harbor Laboratory Press
- DOI
- 10.1101/lm.1572710
- PMID
- 20154353
- PMCID
- PMC2825698
- ISSN
- 1072-0502
- eISSN
- 1549-5485
- Language
- English
- Date published
- 02/2010
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065753302771
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