Journal article
Ventricular Obstruction: Effect on Drinking Induced by Intracranial Injection of Angiotensin
Science (American Association for the Advancement of Science), Vol.190(4209), pp.72-74
10/03/1975
DOI: 10.1126/science.1166302
PMID: 1166302
Abstract
Lesions of the subfornical organ (SFO) severely attenuated drinking induced by injections of angiotensin II into the lateral ventricles, but a few days (4 to 14) later a recovery of the drinking response is observed. A possible explanation for this is that other dipsogenic sites are involved which are beyond the interventricular foramen and that SFO lesions produce an obstruction by edema or debris at the foramen which blocks access of cerebrospinal fluid-borne angiotensin to those sites. This hypothesis is supported by tracer studies and by direct injection into the third ventricle of SFO-lesioned animals. Other studies reported implicate the anteroventral third ventricle as a likely site for angiotensin receptors.
Details
- Title: Subtitle
- Ventricular Obstruction: Effect on Drinking Induced by Intracranial Injection of Angiotensin
- Creators
- James Buggy - Psychobiology Program, Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213Alan E Fisher - Psychobiology Program, Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213William E Hoffman - Neurobehavior Laboratory, Department of Physiology and Biophysics, and Department of Psychology, University of Iowa, Iowa City 52242Alan Kim Johnson - Neurobehavior Laboratory, Department of Physiology and Biophysics, and Department of Psychology, University of Iowa, Iowa City 52242M. Ian Phillips - Neurobehavior Laboratory, Department of Physiology and Biophysics, and Department of Psychology, University of Iowa, Iowa City 52242
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.190(4209), pp.72-74
- DOI
- 10.1126/science.1166302
- PMID
- 1166302
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 10/03/1975
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213278402771
Metrics
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