Journal article
Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms
The American journal of psychiatry, Vol.139(3), pp.297-302
03/1982
DOI: 10.1176/ajp.139.3.297
PMID: 7058942
Abstract
The authors explored the clinical correlates of ventricular enlargement in schizophrenia by comparing 16 patients with "large" ventricles (ventricles more than I SD above the control mean) with 16 patients with the smallest ventricles from a sample of 52 schizophrenic patients. Patients with ventricular enlargement showed some impairment in the sensorium and had a preponderance of "negative" symptoms (e.g., alogia, affective flattening, avolition, anhedonia), while those with small ventricles were characterized by "positive" symptoms (e.g., delusions, hallucinations, positive formal thought disorder, bizarre behavior). These findings suggest that combining a measure of brain structure with the clinical picture may provide a useful new approach to the classification of schizophrenia.
Details
- Title: Subtitle
- Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms
- Creators
- N C AndreasenS A OlsenJ W DennertMichael R Smith
- Resource Type
- Journal article
- Publication Details
- The American journal of psychiatry, Vol.139(3), pp.297-302
- Publisher
- United States
- DOI
- 10.1176/ajp.139.3.297
- PMID
- 7058942
- ISSN
- 0002-953X
- eISSN
- 1535-7228
- Grant note
- RR-59 / NCRR NIH HHS MH-31593 / NIMH NIH HHS
- Language
- English
- Date published
- 03/1982
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003460502771
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