Journal article
Verbal episodic memory declines prior to diagnosis in Huntington's disease
Neuropsychologia, Vol.45(8), pp.1767-1776
2007
DOI: 10.1016/j.neuropsychologia.2006.12.015
PMCID: PMC2570315
PMID: 17303196
Abstract
Previous studies of verbal episodic memory in pre-diagnostic Huntington's disease (HD) have yielded mixed results; some evidence suggests that memory decline is evident prior to the onset of pronounced neurological signs of HD, whereas other data indicate that memory function remains normal throughout the pre-diagnostic period. This study examines verbal episodic memory in a sample of CAG expanded individuals who have not yet been clinically diagnosed, and who represent a wide range of points along the continuum from health to disease. The Hopkins Verbal Learning Test—Revised (HVLT-R) was administered to 479 participants (428 with the HD CAG expansion and 51 without), and performance was compared to neurobiological indices of disease progression, including a DNA-based estimate of proximity to clinical diagnosis, magnetic resonance imaging (MRI) measures of striatal volume, and neurologist ratings of motor signs. Lower HVLT-R scores were associated with closer proximity to clinical diagnosis and smaller striatal volumes; these relationships were found even in groups with no neurological signs of HD. The CAG expanded groups, including those with only minimal neurological signs, had significantly lower HVLT-R scores than the control group, and performance was worse in sub-groups that had more neurological signs consistent with HD. These findings indicate that verbal episodic memory is affected in early pre-diagnostic HD and may decline as striatal volumes decrease and individuals approach the motor diagnostic threshold.
Details
- Title: Subtitle
- Verbal episodic memory declines prior to diagnosis in Huntington's disease
- Creators
- Andrea C Solomon - Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th Street, Bloomington, IN 47405, United StatesJulie C Stout - Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th Street, Bloomington, IN 47405, United StatesShannon A Johnson - Department of Psychological and Brain Sciences, Indiana University, 1101 E. 10th Street, Bloomington, IN 47405, United StatesDouglas R Langbehn - Department of Psychiatry, University of Iowa, United StatesElizabeth H Aylward - Department of Radiology, University of Washington, United StatesJason Brandt - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, United StatesChristopher A Ross - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, United StatesLeigh Beglinger - Department of Psychiatry, University of Iowa, United StatesMichael R Hayden - Center for Molecular Medicine and Therapeutics, University of British Columbia, CanadaKarl Kieburtz - Department of Neurology, University of Rochester, United StatesElise Kayson - Clinical Trials Coordination Center, University of Rochester, United StatesElaine Julian-Baros - Clinical Trials Coordination Center, University of Rochester, United StatesKevin Duff - Department of Psychiatry, University of Iowa, United StatesMark Guttman - Center for Addiction and Mental Health, Toronto, CanadaMartha Nance - Struthers Parkinson's Center, Hennepin County Medical Center, United StatesDavid Oakes - Department of Biostatistics and Computational Biology, University of Rochester, United StatesIra Shoulson - Department of Neurology, University of Rochester, United StatesElizabeth Penziner - Department of Psychiatry, University of Iowa, United StatesJane S Paulsen - Department of Psychiatry, University of Iowa, United StatesPredict-HD investigators of the Huntington Study Group (Institution)
- Contributors
- Hans J Johnson (Contributor) - University of Iowa, Electrical and Computer Engineering
- Resource Type
- Journal article
- Publication Details
- Neuropsychologia, Vol.45(8), pp.1767-1776
- DOI
- 10.1016/j.neuropsychologia.2006.12.015
- PMID
- 17303196
- PMCID
- PMC2570315
- NLM abbreviation
- Neuropsychologia
- ISSN
- 0028-3932
- eISSN
- 1873-3514
- Publisher
- Elsevier BV
- Language
- English
- Date published
- 2007
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative
- Record Identifier
- 9984003452402771
Metrics
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