Journal article
Views of dermatopathologists about clonality assays in the diagnosis of cutaneous T‐cell and B‐cell lymphoproliferative disorders
Journal of cutaneous pathology, Vol.45(1), pp.39-47
01/2018
DOI: 10.1111/cup.13072
PMID: 29084365
Abstract
Background
Appropriate use criteria have been developed for many tests using expert judgment, evidence‐based practice and clinical experience. In this context, we report the opinions of practitioners about clonality assays in various clinical scenarios where cutaneous lymphoma is suspected.
Methods
An Appropriate Use Criteria Task Force sponsored by the American Society of Dermatopathology (ASDP) synthesized clinical scenarios for cutaneous lymphoproliferative disorders (LPDs). We conducted, summarized and presented a relevant literature search to an audience of 144 dermatopathologists with a variety of practice experiences at the 53rd Annual Meeting of the ASDP in Chicago, IL.
Results
Twenty‐seven clinical scenarios for LPDs (13 T‐cell and 14 B‐cell) were defined. Forty relevant studies for T‐cell receptor gene clonality assays and 20 relevant studies for IgH/IgK clonality assays were identified. Audience response data from participating dermatopathologists reflected a wide variety of approaches to the application of clonality assays in the evaluation of LPDs, based on practice setting, personal experience and test availability.
Conclusions
Our clinical scenario analysis and literature review revealed well‐supported clinical scenarios and identified opportunities for additional research to further define the utility of clonality assays in some clinical scenarios.
Details
- Title: Subtitle
- Views of dermatopathologists about clonality assays in the diagnosis of cutaneous T‐cell and B‐cell lymphoproliferative disorders
- Creators
- Nneka Comfere - Mayo ClinicUma Sundram - Oakland University William Beaumont School of Medicine and Beaumont Health SystemsMaria Yadira Hurley - Saint Louis UniversityBrian Swick - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of cutaneous pathology, Vol.45(1), pp.39-47
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- DOI
- 10.1111/cup.13072
- PMID
- 29084365
- ISSN
- 0303-6987
- eISSN
- 1600-0560
- Number of pages
- 9
- Language
- English
- Date published
- 01/2018
- Academic Unit
- Dermatology; Pathology
- Record Identifier
- 9984025442202771
Metrics
19 Record Views