Journal article
Vinculin--a dynamic regulator of cell adhesion
Trends in biochemical sciences (Amsterdam. Regular ed.), Vol.29(11), pp.565-567
11/2004
DOI: 10.1016/j.tibs.2004.09.001
PMID: 15501673
Abstract
The ability of cells to tightly adhere to one another and to the extracellular matrix is fundamentally important in numerous biological processes, including embryogenesis, wound healing and maintenance of tissue integrity. Vinculin, a protein localized at the cytoplasmic face of cell-matrix and cell-cell adhesions, is required for strong cell adhesion. Two new crystal structures reveal that vinculin exhibits a high degree of structural plasticity upon ligand binding that might promote rapid changes in cell adhesion.
Details
- Title: Subtitle
- Vinculin--a dynamic regulator of cell adhesion
- Creators
- Kris A Demali - Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. kdemali@med.unc.edu
- Resource Type
- Journal article
- Publication Details
- Trends in biochemical sciences (Amsterdam. Regular ed.), Vol.29(11), pp.565-567
- Publisher
- England
- DOI
- 10.1016/j.tibs.2004.09.001
- PMID
- 15501673
- ISSN
- 0968-0004
- eISSN
- 1362-4326
- Language
- English
- Date published
- 11/2004
- Academic Unit
- Dermatology; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
- Record Identifier
- 9984025298302771
Metrics
11 Record Views