Journal article
Vinculin in cell-cell and cell-matrix adhesions
Cellular and molecular life sciences : CMLS, Vol.74(16), pp.2999-3009
08/2017
DOI: 10.1007/s00018-017-2511-3
PMCID: PMC5501900
PMID: 28401269
Abstract
Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. We also highlight the recent understanding of how vinculin responds to and transmits force at integrin- and cadherin-containing adhesion complexes to the cytoskeleton. Furthermore, we discuss roles of vinculin in binding to and rearranging the actin cytoskeleton.
Details
- Title: Subtitle
- Vinculin in cell-cell and cell-matrix adhesions
- Creators
- Jennifer L Bays - Department of Biochemistry, University of Iowa, Iowa City, IA, 52242, USAKris A DeMali - Department of Biochemistry, University of Iowa, Iowa City, IA, 52242, USA. kris-demali@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Cellular and molecular life sciences : CMLS, Vol.74(16), pp.2999-3009
- DOI
- 10.1007/s00018-017-2511-3
- PMID
- 28401269
- PMCID
- PMC5501900
- NLM abbreviation
- Cell Mol Life Sci
- ISSN
- 1420-682X
- eISSN
- 1420-9071
- Publisher
- Switzerland
- Grant note
- R01 GM112805 / NIGMS NIH HHS P41 EB002025 / NIBIB NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 08/2017
- Academic Unit
- Dermatology; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
- Record Identifier
- 9984025261202771
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