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Viral co-infections and paraproteins in HIV: effect on development of hematological malignancies
Journal article   Peer reviewed

Viral co-infections and paraproteins in HIV: effect on development of hematological malignancies

Erin Jou, Oleg Gligich, Alvita C Y Chan, Diwakar Mohan, Uriel R Felsen, Sabarish Ayyappan, Henny H Billett, Edwin P Hui, Anthony T C Chan and Radha Raghupathy
Annals of hematology, Vol.95(4), pp.575-580
03/2016
DOI: 10.1007/s00277-016-2588-z
PMCID: PMC4944817
PMID: 26747296
url
https://www.ncbi.nlm.nih.gov/pmc/articles/4944817View
Open Access

Abstract

The role of viral co-infections and paraproteins in the development of hematological malignancies (HMs) in HIV remains unclear. Using our large database of HIV+ patients, we investigated whether co-infection and paraproteinemia increase the risk of HM. Data on demographics, hepatitis B (HBV) and hepatitis C virus (HCV) co-infections, paraproteinemia, HIV characteristics, and biopsy proven malignant hematological disorders for HIV+ patients were collected over a 10-year period in a large urban hospital setting. We identified 10,293 HIV+ patients who were followed for a median duration of 53 months. Of the 10,293 patients with HIV, 229 (2.2 %) were diagnosed with a HM. Over 85 % of patients in both groups were tested; no significant difference in the prevalence of chronic HBV or HCV was noted between the HM positive (n = 229) and HM negative (n = 9992) patients. The serum protein electrophoresis test was performed for 1371 of the 10,221 patients. HM positive patients, compared to HM negative, were more likely to be tested for paraproteins (OR 3.3, 95 % CI 2.5-4.4) and more likely to have a discrete paraprotein band (OR 3.3, 95 % CI 1.2-8.9). Discrete paraproteins exclusively correlated with the development of plasma cell malignancies. Faint or oligoclonal protein bands were seen in high grade B cell lymphomas but did not show a significant correlation with HM development. Chronic hepatitis B or C infections did not correlate with the development of HM in HIV; however, viral influence on host gene transformation may have been impacted by anti-viral therapy limiting the duration of high viremic states.
 Adult Cohort Studies Coinfection - blood Coinfection - diagnosis Coinfection - epidemiology Female Follow-Up Studies Hematologic Neoplasms - blood Hematologic Neoplasms - diagnosis Hematologic Neoplasms - epidemiology Hepatitis B - blood Hepatitis B - diagnosis Hepatitis B - epidemiology Hepatitis C - blood Hepatitis C - diagnosis Hepatitis C - epidemiology HIV Infections - blood HIV Infections - diagnosis HIV Infections - epidemiology Humans Male Middle Aged Paraproteins - metabolism

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