Journal article
Viral induced fusion and syncytium formation: measurement by the Kolmogorov–Smirnov statistical test
Journal of virological methods, Vol.111(2), pp.157-161
2003
DOI: 10.1016/S0166-0934(03)00152-6
PMID: 12880931
Abstract
Fusion and syncytium formation induced by the expression of fusogenic viral glycoproteins are common cytopathic effects. Numerous laboratories have studied mechanisms of fusion, generally with each laboratory utilizing a different method to measure polykaryote formation. There is little consensus as to which methods are preferred for measuring and comparing fusion. The Kolmogorov–Smirnov two-sample test was used to document a statistical difference in syncytium formation between two forms of a varicella-zoster virus (VZV) fusogenic glycoprotein. This test is widely applied toward the analysis of large human populations in which interest centers on testing the hypothesis that the distributions of two sub-populations are identical. We suggest that the Kolmogorov–Smirnov test is a preferable method to assess whether differences in distribution of syncytia size between two fusogenic glycoproteins are meaningful statistically.
Details
- Title: Subtitle
- Viral induced fusion and syncytium formation: measurement by the Kolmogorov–Smirnov statistical test
- Creators
- Tracy Jo Pasieka - Departments of Microbiology and Pediatrics, University of Iowa Hospital/2501 JCP, 200 Hawkins Drive, Iowa City, IA 52242, USARobert F Woolson - Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC, USACharles Grose - Departments of Microbiology and Pediatrics, University of Iowa Hospital/2501 JCP, 200 Hawkins Drive, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Journal of virological methods, Vol.111(2), pp.157-161
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0166-0934(03)00152-6
- PMID
- 12880931
- ISSN
- 0166-0934
- eISSN
- 1879-0984
- Language
- English
- Date published
- 2003
- Academic Unit
- Statistics and Actuarial Science; Stead Family Department of Pediatrics; Epidemiology; Biostatistics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093318002771
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