Viral manipulation of the host immune response

Allison Christiaansen; Steven M Varga; Juliet V Spencer

doi:10.1016/j.coi.2015.06.012

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Viral manipulation of the host immune response

Journal article

Peer reviewed

Viral manipulation of the host immune response

Allison Christiaansen, Steven M Varga and Juliet V Spencer

Current opinion in immunology, Vol.36, pp.54-60

10/2015

DOI: 10.1016/j.coi.2015.06.012

PMCID: PMC4593765

PMID: 26177523

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Abstract

Viruses are obligate intracellular parasites that require a host for essential machinery to replicate and ultimately be transmitted to new susceptible hosts. At the same time, the immune system has evolved to protect the human body from invasion by viruses and other pathogens. To counter this, viruses have developed an arsenal of strategies to not only avoid immune detection but to actively manipulate host immune responses to create an environment more favorable for infection. Here, we describe recent advances uncovering novel mechanisms by which viruses skew host immune responses through modulation of cytokine and chemokine signaling networks, interference with antigen presentation and T cell responses, and preventing antibody production.

Signal Transduction

T-Lymphocyte Subsets - immunology

Virus Diseases - immunology

Cytokines - metabolism

Immunomodulation

Humans

Virus Diseases - metabolism

Virus Diseases - virology

Immunity

Host-Pathogen Interactions - immunology

Animals

B-Lymphocyte Subsets - metabolism

Host-Pathogen Interactions - genetics

T-Lymphocyte Subsets - metabolism

Inflammation Mediators - metabolism

B-Lymphocyte Subsets - immunology

Virus Physiological Phenomena

Virus Diseases - genetics

Details

Title: Subtitle: Viral manipulation of the host immune response
Creators: Allison Christiaansen - Department of Microbiology, The University of Iowa, 51 Newton Road, 3-532 Bowen Science Building, Iowa City, IA 52242, USA
Steven M Varga - Department of Microbiology, The University of Iowa, 51 Newton Road, 3-532 Bowen Science Building, Iowa City, IA 52242, USA; Department of Pathology, The University of Iowa, 51 Newton Road, 3-532 Bowen Science Building, Iowa City, IA 52242, USA; Interdisciplinary Graduate Program in Immunology, The University of Iowa, 51 Newton Road, 3-532 Bowen Science Building, Iowa City, IA 52242, USA
Juliet V Spencer - Department of Biology, University of San Francisco, Harney Science Center, 2130 Fulton Street, San Francisco, CA 94117, USA. Electronic address: jspencer@usfca.edu
Resource Type: Journal article
Publication Details: Current opinion in immunology, Vol.36, pp.54-60
DOI: 10.1016/j.coi.2015.06.012
PMID: 26177523
PMCID: PMC4593765
NLM abbreviation: Curr Opin Immunol
ISSN: 0952-7915
eISSN: 1879-0372
Publisher: Elsevier BV
Grant note: R15 AI111232 / NIAID NIH HHS AI111232 / NIAID NIH HHS T32 AI007533 / NIAID NIH HHS
Language: English
Date published: 10/2015
Academic Unit: Graduate College Admin and Gen; Microbiology and Immunology; Pathology
Record Identifier: 9984083274702771

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