Journal article
Viral vector vaccines make memory T cells against malaria
Immunology, Vol.121(2), pp.158-165
06/2007
DOI: 10.1111/j.1365-2567.2006.02552.x
PMCID: PMC2265939
PMID: 17462077
Abstract
Vaccines that comprise attenuated viral vectors encoding antigens from target pathogens generate potent T-cell responses. One such pathogen is malaria, and in particular the liver stage of its life cycle. Immunogenicity and efficacy studies in animals and humans have revealed the generation of memory T cells of both the central and effector phenotypes, depending on the viral vectors used in the malaria vaccination regime (viral species and serotype, combination and sequence for prime-boost) and suggest a divergence in their protective role. Being able to influence the memory T-cell make-up in a rational manner may allow us to develop more efficacious vaccines.
Details
- Title: Subtitle
- Viral vector vaccines make memory T cells against malaria
- Creators
- Arturo Reyes-Sandoval - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UKJohn T HartyStephen M Todryk
- Resource Type
- Journal article
- Publication Details
- Immunology, Vol.121(2), pp.158-165
- DOI
- 10.1111/j.1365-2567.2006.02552.x
- PMID
- 17462077
- PMCID
- PMC2265939
- NLM abbreviation
- Immunology
- ISSN
- 0019-2805
- eISSN
- 1365-2567
- Publisher
- England
- Grant note
- Wellcome Trust
- Language
- English
- Date published
- 06/2007
- Academic Unit
- Pathology
- Record Identifier
- 9984047717202771
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