Journal article
Virological response for recurrent hepatitis C improves long-term survival in liver transplant recipients
Transplant international, Vol.26(1), pp.42-49
01/2013
DOI: 10.1111/j.1432-2277.2012.01571.x
PMID: 23137287
Abstract
Recurrent hepatitis C virus (HCV) infection occurs universally and is regarded as a major cause of mortality after liver transplantation (LT) for HCV-related end-stage liver disease. We conducted this large, single-center, retrospective study to ascertain the long-term impact of virological response to treatment of recurrent hepatitis C on survival of LT recipients. From August 1987 to October 2011, 285 patients have received interferon-based antiviral therapy for recurrent hepatitis C. Of these 285, 245 patients were enrolled in this study. One hundred and twenty-six patients (51.4%) achieved sustained virological response (SVR). Relapsers (undetectable HCV-RNA at end of treatment, becoming positive afterward) comprised 9.0% (22/245), and nonresponse (NR; never achieving undetectable HCV-RNA) 39.6% (97/245). The median follow-up after completion of antiviral treatment was 2081 days. Using Kaplan-Meier method, patients who achieved SVR were shown to have significantly better 5-year patient survival (95.2%) than the NR group (49.9%) (P < 0.001), and a trend toward better 5-year survival than relapsers (87.5%) (P = 0.14); relapsers had a significantly longer survival than NR group (P = 0.005). When compared with NR, SVR and relapse appeared to be significant predictors of better survival, independent of underlying characteristics. In conclusion, virological response, especially SVR, translates into markedly improved long-term patient outcomes in patients transplanted for hepatitis C.
Details
- Title: Subtitle
- Virological response for recurrent hepatitis C improves long-term survival in liver transplant recipients
- Creators
- Tomohiro Tanaka - Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, CanadaNazia SelznerGeorge TherapondosEberhard L RennerLeslie B Lilly
- Resource Type
- Journal article
- Publication Details
- Transplant international, Vol.26(1), pp.42-49
- DOI
- 10.1111/j.1432-2277.2012.01571.x
- PMID
- 23137287
- ISSN
- 0934-0874
- eISSN
- 1432-2277
- Language
- English
- Date published
- 01/2013
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984094577102771
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