Journal article
Virology under the Microscope—a Call for Rational Discourse
mSphere, Vol.8(2), e00034-23
04/20/2023
DOI: 10.1128/msphere.00034-23
PMCID: PMC10117089
PMID: 36700653
Abstract
Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals.
ABSTRACT Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the field of virology. Some of this attention is focused on concern about the safe conduct of research with human pathogens. A small but vocal group of individuals has seized upon these concerns – conflating legitimate questions about safely conducting virus-related research with uncertainties over the origins of SARS-CoV-2. The result has fueled public confusion and, in many instances, ill-informed condemnation of virology. With this article, we seek to promote a return to rational discourse. We explain the use of gain-of-function approaches in science, discuss the possible origins of SARS-CoV-2 and outline current regulatory structures that provide oversight for virological research in the United States. By offering our expertise, we – a broad group of working virologists – seek to aid policy makers in navigating these controversial issues. Balanced, evidence-based discourse is essential to addressing public concern while maintaining and expanding much-needed research in virology.
Details
- Title: Subtitle
- Virology under the Microscope—a Call for Rational Discourse
- Creators
- Felicia Goodrum - University of ArizonaAnice Lowen - Emory UniversitySeema Lakdawala - Emory UniversityJames Alwine - University of ArizonaArturo Casadevall - Johns Hopkins UniversityMichael Imperiale - University of MichiganWalter Atwood - Brown UniversityDaphne Avgousti - Fred Hutch Cancer CenterJoel Baines - Cornell UniversityBruce Banfield - Queen's UniversityLawrence Banks - International Centre for Genetic Engineering and BiotechnologySumita Bhaduri-McIntosh - University of FloridaDeepta Bhattacharya - University of ArizonaDaniel Blanco-Melo - Fred Hutch Cancer CenterDavid Bloom - University of FloridaAdrianus Boon - University of Illinois Urbana-ChampaignSteeve Boulant - University of FloridaCurtis Brandt - University of Wisconsin–MadisonAndrew Broadbent - University of Maryland.Christopher Brooke - University of Illinois Urbana-ChampaignCraig Cameron - University of North Carolina.Samuel Campos - University of ArizonaPatrizia Caposio - Oregon Health & Science UniversityGary Chan - SUNY Upstate Medical UniversityAnna Cliffe - University of VirginiaJohn Coffin - Tufts UniversityKathleen Collins - University of MichiganBlossom Damania - University of North Carolina.Michael Daugherty - University of California San DiegoKari Debbink - Johns Hopkins UniversityJames DeCaprio - Harvard UniversityTerence Dermody - University of PittsburghJimmy Dikeakos - Western University.Daniel DiMaio - Yale UniversityRhoel Dinglasan - University of FloridaW. Paul Duprex - University of PittsburghRebecca Dutch - University of KentuckyNels Elde - University of UtahMichael Emerman - Fred Hutch Cancer CenterLynn Enquist - Princeton UniversityBentley Fane - University of ArizonaAna Fernandez-Sesma - Icahn School of Medicine at Mount SinaiMichelle Flenniken - Montana State UniversityLori Frappier - University of TorontoMatthew Frieman - University of Maryland.Klaus Frueh - Oregon Health & Science UniversityMichaela Gack - Meridien ResearchMarta Gaglia - University of Wisconsin–MadisonTom Gallagher - Loyola University ChicagoDenise Galloway - Fred Hutch Cancer CenterAdolfo García-Sastre - Icahn School of Medicine at Mount SinaiAdam Geballe - Fred Hutch Cancer CenterBritt Glaunsinger - University of California, BerkeleyStephen Goff - Columbia UniversityAlexander Greninger - University of WashingtonMeaghan Hancock - Oregon Health & Science UniversityEva Harris - University of California, BerkeleyNicholas Heaton - Duke UniversityMark Heise - University of North Carolina.Ekaterina Heldwein - Tufts UniversityBrenda Hogue - Arizona State UniversityStacy Horner - Duke UniversityEdward Hutchinson - University of GlasgowJoseph Hyser - Baylor UniversityWilliam Jackson - Arizona State UniversityRobert Kalejta - Duke UniversityJeremy Kamil - Louisiana State UniversityStephanie Karst - University of FloridaFrank Kirchhoff - Universität UlmDavid Knipe - Harvard UniversityTimothy Kowalik - University of Massachusetts BostonMichael Lagunoff - University of WashingtonLaimonis Laimins - Northwestern MedicineRyan Langlois - University of MinnesotaAdam Lauring - University of MichiganBenhur Lee - Icahn School of Medicine at Mount SinaiDavid Leib - Dartmouth CollegeShan-Lu Liu - The Ohio State UniversityRichard Longnecker - Northwestern MedicineCarolina Lopez - Washington University.Micah Luftig - Duke UniversityJennifer Lund - Fred Hutch Cancer CenterBalaji Manicassamy - University of IowaGrant McFadden - Arizona State UniversityMichael McIntosh - University of FloridaAndrew Mehle - University of Wisconsin–MadisonW. Allen Miller - Iowa State UniversityIan Mohr - New York UniversityCary Moody - University of North Carolina.Nathaniel Moorman - University of North Carolina.Anne Moscona - Columbia UniversityBryan Mounce - Loyola University ChicagoJoshua Munger - University of RochesterKarl Münger - Tufts UniversityEain Murphy - SUNY Upstate Medical UniversityMojgan Naghavi - Northwestern MedicineJay Nelson - Oregon Health & Science UniversityChristopher Neufeldt - Emory UniversityJanko Nikolich - University of ArizonaChristine O'Connor - Cleveland ClinicAkira Ono - University of MichiganWalter Orenstein - Emory UniversityDavid Ornelles - Wake Forest UniversityJing-hsiung Ou - University of Southern CaliforniaJohn Parker - Cornell UniversityColin Parrish - Cornell UniversityAndrew Pekosz - Johns Hopkins UniversityPhilip Pellett - Wayne State UniversityJulie Pfeiffer - The University of Texas at AustinRichard Plemper - Georgia State UniversityStephen Polyak - University of WashingtonJohn Purdy - University of ArizonaDohun Pyeon - Michigan State UniversityMiguel Quinones-Mateu - Western University.Rolf Renne - University of FloridaCharles Rice - Rockefeller UniversityJohn Schoggins - The University of Texas at AustinRichard Roller - University of IowaCharles Russell - St. Jude Children's Research HospitalRozanne Sandri-Goldin - University of California, IrvineMartin Sapp - Louisiana State UniversityLuis Schang - Cornell UniversityScott Schmid - University of Colorado BoulderStacey Schultz-Cherry - St. Jude Children's Research HospitalBert Semler - University of California, IrvineThomas Shenk - Princeton UniversityGuido Silvestri - University of KentuckyViviana Simon - Icahn School of Medicine at Mount SinaiGregory Smith - Northwestern MedicineJason Smith - University of WashingtonKatherine Spindler - University of MinnesotaMegan Stanifer - University of FloridaKanta Subbarao - Peter Doherty InstituteWesley Sundquist - University of UtahMehul Suthar - Emory UniversityTroy Sutton - Pennsylvania State UniversityAndrew Tai - University of MichiganVera Tarakanova - Medical College of WisconsinBenjamin tenOever - New York UniversityScott Tibbetts - University of FloridaStephen Tompkins - University of GeorgiaZsolt Toth - University of FloridaKoenraad van Doorslaer - University of ArizonaMarco Vignuzzi - Agency for Science, Technology and ResearchNicholas Wallace - Kansas State UniversityDerek Walsh - Northwestern MedicineMichael Weekes - University of CambridgeJason Weinberg - University of MichiganMatthew Weitzman - University of PennsylvaniaSandra Weller - University of ConnecticutSean Whelan - Washington UniversityElizabeth White - University of PennsylvaniaBryan Williams - Monash UniversityChristiane Wobus - University of MichiganScott Wong - Oregon Health & Science UniversityAndrew Yurochko - Louisiana State University
- Resource Type
- Journal article
- Publication Details
- mSphere, Vol.8(2), e00034-23
- DOI
- 10.1128/msphere.00034-23
- PMID
- 36700653
- PMCID
- PMC10117089
- NLM abbreviation
- mSphere
- ISSN
- 2379-5042
- eISSN
- 2379-5042
- Language
- English
- Electronic publication date
- 01/26/2023
- Date published
- 04/20/2023
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984363739202771
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