Virtual Brain Projection for Evaluating Trans-skull Beam Behavior of Transcranial Ultrasound Devices

Spencer T Brinker; Frank Preiswerk; Nathan J McDannold; Krystal L Parker; Timothy Y Mariano

doi:10.1016/j.ultrasmedbio.2019.03.009

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Virtual Brain Projection for Evaluating Trans-skull Beam Behavior of Transcranial Ultrasound Devices

Journal article

Peer reviewed

Virtual Brain Projection for Evaluating Trans-skull Beam Behavior of Transcranial Ultrasound Devices

Spencer T Brinker, Frank Preiswerk, Nathan J McDannold, Krystal L Parker and Timothy Y Mariano

Ultrasound in medicine & biology, Vol.45(7), pp.1850-1856

07/2019

DOI: 10.1016/j.ultrasmedbio.2019.03.009

PMID: 31060860

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https://www.ncbi.nlm.nih.gov/pmc/articles/6827342View

Open Access

Abstract

Focused ultrasound single-element piezoelectric transducers constitute a promising method to deliver ultrasound to the brain in low-intensity applications, but are subject to defocusing and high attenuation because of transmission through the skull. Here, a novel virtual brain projection method is used to superimpose a magnetic resonance image of the brain in ex vivo human skulls to provide targets during trans-skull focused ultrasound single-element piezoelectric transducer pressure field mapping. Positions of the transducer, skull and hydrophone are tracked in real time using a stereoscopic navigation camera and 3-D Slicer software. Virtual targets of the left dorsolateral prefrontal cortex, left hippocampus and cerebellar vermis were chosen to illustrate the method's flexibility in evaluating focal-zone beam distortion and attenuation. The regions are of interest as non-invasive brain stimulation targets in the treatment of neuropsychiatric disorders via repeated ultrasound exposure. The technical approach can facilitate the assessment of transcranial ultrasound device operator positioning reliability, intracranial beam behavior and computational model validation.

Dorsolateral prefrontal cortex

Transcranial ultrasound

Cerebellar vermis

Virtual brain projection

Hippocampus

Details

Title: Subtitle: Virtual Brain Projection for Evaluating Trans-skull Beam Behavior of Transcranial Ultrasound Devices
Creators: Spencer T Brinker - Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Frank Preiswerk - Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nathan J McDannold - Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Krystal L Parker - Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Timothy Y Mariano - Department of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Resource Type: Journal article
Publication Details: Ultrasound in medicine & biology, Vol.45(7), pp.1850-1856
DOI: 10.1016/j.ultrasmedbio.2019.03.009
PMID: 31060860
NLM abbreviation: Ultrasound Med Biol
ISSN: 0301-5629
eISSN: 1879-291X
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health
Language: English
Date published: 07/2019
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984070266402771

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