Journal article
Virulence of a Salmonella typhimurium OmpD Mutant
Infection and immunity, Vol.66(1), pp.387-390
Note
01/01/1998
DOI: 10.1128/iai.66.1.387-390.1998
PMCID: PMC107915
PMID: 9423887
Abstract
An
ompD
mutation caused by a Tn
10
insertion was transduced into
Salmonella typhimurium
SL1344 and UK-1. The adherence and invasion capabilities of the resultant
ompD
mutants were examined by tissue culture analysis. The virulence of the
S. typhimurium ompD
mutants was ascertained by a 50% lethal dose (LD
50
) study and by determining colonization ability with BALB/c mice. We found no statistically significant difference in adherence and invasion capacities between the
S. typhimurium
wild type strains and their corresponding
ompD
mutants. Furthermore, the LD
50
and colonization studies revealed that there is no statistically significant difference in virulence between the
S. typhimurium
wild type strains and their corresponding
ompD
mutants. These results differ from those reported previously (C. J. Dorman, S. Chatfield, C. F. Higgins, C. Hayward, and G. Dougan, Infect. Immun. 57:2136–2140, 1989).
Details
- Title: Subtitle
- Virulence of a Salmonella typhimurium OmpD Mutant
- Creators
- Paul N. Meyer - Department of Biology, Washington University, St. Louis, Missouri 63130Mary R. Wilmes-Riesenberg - Department of Biology, Washington University, St. Louis, Missouri 63130Christos Stathopoulos - Department of Biology, Washington University, St. Louis, Missouri 63130Roy Curtiss - Department of Biology, Washington University, St. Louis, Missouri 63130
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.66(1), pp.387-390
- Series
- Note
- DOI
- 10.1128/iai.66.1.387-390.1998
- PMID
- 9423887
- PMCID
- PMC107915
- NLM abbreviation
- Infect Immun
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Publisher
- American Society for Microbiology
- Number of pages
- 4
- Language
- English
- Date published
- 01/01/1998
- Academic Unit
- Pathology
- Record Identifier
- 9984822980502771
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