Journal article
Virus-Specific Regulatory T Cells Persist as Memory in a Neurotropic Coronavirus Infection
The Journal of immunology (1950), Vol.208(7), ji2100794
04/01/2022
DOI: 10.4049/jimmunol.2100794
PMCID: PMC9012697
PMID: 35365567
Abstract
Regulatory T cells (Tregs) are critical for regulating immunopathogenic responses in a variety of infections, including infection of mice with JHM strain of mouse hepatitis virus (JHMV), a neurotropic coronavirus that causes immune-mediated demyelinating disease. Although virus-specific Tregs are known to mitigate disease in this infection by suppressing pathogenic effector T cell responses of the same specificity, it is unclear whether these virus-specific Tregs form memory populations and persist similar to their conventional T cell counterparts of the same epitope specificity. Using congenically labeled JHMV-specific Tregs, we found that virus-specific Tregs persist long-term after murine infection, through at least 180 d postinfection and stably maintain Foxp3 expression. We additionally demonstrate that these cells are better able to proliferate and inhibit virus-specific T cell responses postinfection than naive Tregs of the same specificity, further suggesting that these cells differentiate into memory Tregs upon encountering cognate Ag. Taken together, these data suggest that virus-specific Tregs are able to persist long-term in the absence of viral Ag as memory Tregs.
Details
- Title: Subtitle
- Virus-Specific Regulatory T Cells Persist as Memory in a Neurotropic Coronavirus Infection
- Creators
- Alan Sariol - University of IowaJingxian Zhao - First Affiliated Hospital of Guangzhou Medical UniversityJuan E Abrahante - University of MinnesotaStanley Perlman - Department of Microbiology and Immunology, University of Iowa, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.208(7), ji2100794
- DOI
- 10.4049/jimmunol.2100794
- PMID
- 35365567
- PMCID
- PMC9012697
- NLM abbreviation
- J Immunol
- eISSN
- 1550-6606
- Grant note
- This work was supported in part by National Institute of Neurological Disorders and Stroke Grant R01 NS36592 (to S.P.), National Institute of Allergy and Infectious Diseases Grant T32 AI007260 (to A.S.), National Institutes of Health Grant T32 GM067795 (to A.S.), National Multiple Sclerosis Society Grant RG 5340-A-7 (to S.P.), and National Natural Science Foundation of China Grant 81771694 (to J.Z.).
- Language
- English
- Date published
- 04/01/2022
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9984230415402771
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