Journal article
Virus infection and interferon can activate gene expression through a single synthetic element, but endogenous genes show distinct regulation
The Journal of biological chemistry, Vol.264(28), pp.16658-16666
01/01/1989
DOI: 10.1016/S0021-9258(19)84756-7
PMID: 2550451
Abstract
We have examined the similarities between virus and interferon induction of gene expression and the role of AGTGAA and AAT-GAA hexamers in these responses. Hybrid plasmids were constructed by inserting the IE region, the alpha 4 promoter, or the multiple copies of AGTGAA or AAT-GAA 5' to the inactive -45 human immunodeficiency-chloramphenicol acetyltransferase hybrid gene, and their inducible expression was studied in a transient expression assay. Endogenous interferon may play a role in the autoregulation of both interferon genes and interferon-stimulated genes.
Details
- Title: Subtitle
- Virus infection and interferon can activate gene expression through a single synthetic element, but endogenous genes show distinct regulation
- Creators
- N Babu K RajJohn Engelhardt - Johns Hopkins MedicineWei-Chun Au - Johns Hopkins MedicineDavid E Levy - Johns Hopkins MedicinePaula M Pitha - New York University
- Resource Type
- Journal article
- Publication Details
- The Journal of biological chemistry, Vol.264(28), pp.16658-16666
- DOI
- 10.1016/S0021-9258(19)84756-7
- PMID
- 2550451
- NLM abbreviation
- J Biol Chem
- ISSN
- 0021-9258
- eISSN
- 1083-351X
- Language
- English
- Date published
- 01/01/1989
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984284341402771
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