Journal article
Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages
PLoS pathogens, Vol.10(8), pp.e1004279-e1004279
08/2014
DOI: 10.1371/journal.ppat.1004279
PMCID: PMC4125232
PMID: 25102154
Abstract
Several studies have demonstrated the presence of pathogen-specific Foxp3+ CD4 regulatory T cells (Treg) in infected animals, but little is known about where and how these cells affect the effector T cell responses and whether they are more suppressive than bulk Treg populations. We recently showed the presence of both epitope M133-specific Tregs (M133 Treg) and conventional CD4 T cells (M133 Tconv) in the brains of mice with coronavirus-induced encephalitis. Here, we provide new insights into the interactions between pathogenic Tconv and Tregs responding to the same epitope. M133 Tregs inhibited the proliferation but not initial activation of M133 Tconv in draining lymph nodes (DLN). Further, M133 Tregs inhibited migration of M133 Tconv from the DLN. In addition, M133 Tregs diminished microglia activation and decreased the number and function of Tconv in the infected brain. Thus, virus-specific Tregs inhibited pathogenic CD4 T cell responses during priming and effector stages, particularly those recognizing cognate antigen, and decreased mortality and morbidity without affecting virus clearance. These cells are more suppressive than bulk Tregs and provide a targeted approach to ameliorating immunopathological disease in infectious settings.
Details
- Title: Subtitle
- Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages
- Creators
- Jingxian Zhao - Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of AmericaJincun Zhao - Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of AmericaStanley Perlman - Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
- Resource Type
- Journal article
- Publication Details
- PLoS pathogens, Vol.10(8), pp.e1004279-e1004279
- DOI
- 10.1371/journal.ppat.1004279
- PMID
- 25102154
- PMCID
- PMC4125232
- NLM abbreviation
- PLoS Pathog
- ISSN
- 1553-7366
- eISSN
- 1553-7374
- Publisher
- United States
- Grant note
- R01 NS036592 / NINDS NIH HHS\r\nNS036592 / NINDS NIH HHS
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9983777349802771
Metrics
19 Record Views