Journal article
Visual Outcomes in Experimental Rodent Models of Blast-Mediated Traumatic Brain Injury
Frontiers in molecular neuroscience, Vol.14, pp.659576-659576
2021
DOI: 10.3389/fnmol.2021.659576
PMCID: PMC8081965
PMID: 33935648
Abstract
Blast-mediated traumatic brain injuries (bTBI) cause long-lasting physical, cognitive, and psychological disorders, including persistent visual impairment. No known therapies are currently utilized in humans to lessen the lingering and often serious symptoms. With TBI mortality decreasing due to advancements in medical and protective technologies, there is growing interest in understanding the pathology of visual dysfunction after bTBI. However, this is complicated by numerous variables, e.g., injury location, severity, and head and body shielding. This review summarizes the visual outcomes observed by various, current experimental rodent models of bTBI, and identifies data showing that bTBI activates inflammatory and apoptotic signaling leading to visual dysfunction. Pharmacologic treatments blocking inflammation and cell death pathways reported to alleviate visual deficits in post-bTBI animal models are discussed. Notably, techniques for assessing bTBI outcomes across exposure paradigms differed widely, so we urge future studies to compare multiple models of blast injury, to allow data to be directly compared.
Details
- Title: Subtitle
- Visual Outcomes in Experimental Rodent Models of Blast-Mediated Traumatic Brain Injury
- Creators
- Lucy P Evans - Department of Pediatrics, University of IowaAriel M Roghair - Department of Pediatrics, University of IowaNoah J Gilkes - Department of Pediatrics, University of IowaAlexander G Bassuk - Department of Pediatrics, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Frontiers in molecular neuroscience, Vol.14, pp.659576-659576
- DOI
- 10.3389/fnmol.2021.659576
- PMID
- 33935648
- PMCID
- PMC8081965
- NLM abbreviation
- Front Mol Neurosci
- ISSN
- 1662-5099
- eISSN
- 1662-5099
- Publisher
- Frontiers Media S.A
- Grant note
- R01NS098590 / National Institute of Neurological Disorders and Stroke EY031245 / National Eye Institute R01AR059703. / National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Language
- English
- Date published
- 2021
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984070366002771
Metrics
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