Journal article
Visual cortical contributions to associative cerebellar learning
Neurobiology of learning and memory, Vol.104, pp.103-109
2013
DOI: 10.1016/j.nlm.2013.06.005
PMCID: PMC3753663
PMID: 23791556
Abstract
Eye-blink conditioning (EBC) is a form of associative learning that depends on the cerebellum. Previous reports suggested that sensory cortex is necessary for trace EBC but not for delay EBC. The trace and delay EBC procedures used in these studies differed by the presence or absence of a temporal gap between the end of the conditioned stimulus and the onset of the unconditioned stimulus (trace interval) and in the interval between the onset of the CS and the US (inter-stimulus interval, ISI). The current study examined the role of the visual cortex in delay, long-delay, and trace EBC, matching CS duration and inter-stimulus interval between groups. In Experiment 1, extensive removal of the visual cortex impaired acquisition of long-delay and trace EBC but had no effect on delay EBC. In Experiment 2, bilateral inactivation of the visual cortex impaired acquisition and retention of long-delay and trace EBC, but had no effect on delay EBC. In Experiment 3, unilateral inactivation of the visual cortex impaired long-delay EBC but had no effect on trace EBC. The results indicate that the visual cortex facilitates EBC with relatively long ISIs, regardless of whether there is a trace interval or not. Moreover, the ipsilateral projections from the visual cortex to the pontine nuclei are sufficient for modulating long-delay EBC, whereas trace EBC involves bilateral visual cortical interactions with forebrain systems including the hippocampus and prefrontal cortex.
Details
- Title: Subtitle
- Visual cortical contributions to associative cerebellar learning
- Creators
- Adam B STEINMETZ - Department of Psychology, University of Iowa, Iowa City, IA 52242, United StatesThomas C HARMON - Department of Psychology, University of Iowa, Iowa City, IA 52242, United StatesJohn H FREEMAN - Department of Psychology, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Neurobiology of learning and memory, Vol.104, pp.103-109
- Publisher
- Elsevier; Amsterdam
- DOI
- 10.1016/j.nlm.2013.06.005
- PMID
- 23791556
- PMCID
- PMC3753663
- ISSN
- 1074-7427
- eISSN
- 1095-9564
- Grant note
- DOI: 10.13039/100000025, name: NIMH, award: MH080005
- Language
- English
- Date published
- 2013
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065862202771
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