Visual outcome following subretinal hemorrhage in Best disease

Mina M Chung; Kean T Oh; Luan M Streb; Alan E Kimura; Edwin M Stone

doi:10.1097/00006982-200112000-00003

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Visual outcome following subretinal hemorrhage in Best disease

Journal article

Peer reviewed

Visual outcome following subretinal hemorrhage in Best disease

Mina M Chung, Kean T Oh, Luan M Streb, Alan E Kimura and Edwin M Stone

Retina (Philadelphia, Pa.), Vol.21(6), pp.575-580

2001

DOI: 10.1097/00006982-200112000-00003

PMID: 11756879

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Abstract

To review cases of Best disease associated with subretinal hemorrhage to better understand their long-term visual prognosis. Patients were identified through the photographic file database at the University of Iowa. Seventy-eight files of patients with clinical evidence of Best disease were reviewed and 12 patients (14 eyes) were identified with subretinal hemorrhage. The visual acuity and clinical course were reviewed in all of these patients when possible. Three patients demonstrated subretinal hemorrhage on their last follow-up visit. Nine patients (11 eyes) were followed through to resolution of subretinal hemorrhage. Eight patients were screened on the VMD2 gene and all were found to have disease-causing sequence variations. All patients noted visual loss at presentation with subretinal hemorrhage (median 20/100; range 20/30-20/400). The median final visual acuity in the 11 eyes with follow-up was 20/50 (20/16-20/400 range). Ten of 11 eyes demonstrated improvement of vision with 9/11 having a final visual acuity of 20/50 or better. The natural history of patients with Best disease with subretinal hemorrhage and moderate visual loss is relatively good. The presence of subretinal hemorrhage in Best disease may be related to mild, incidental trauma.

Retinal Hemorrhage - physiopathology

Prognosis

Retinal Hemorrhage - etiology

Macular Degeneration - physiopathology

Humans

Macular Degeneration - complications

Male

Choroidal Neovascularization - physiopathology

Bestrophins

Chloride Channels

Macular Degeneration - genetics

DNA Mutational Analysis

Adolescent

Adult

Female

Eye Proteins - genetics

Child

Visual Acuity - physiology

Fluorescein Angiography

Details

Title: Subtitle: Visual outcome following subretinal hemorrhage in Best disease
Creators: Mina M Chung - The Department of Ophthalmology, The University of Southern California, Los Angeles, CA, USA
Kean T Oh
Luan M Streb
Alan E Kimura
Edwin M Stone
Resource Type: Journal article
Publication Details: Retina (Philadelphia, Pa.), Vol.21(6), pp.575-580
DOI: 10.1097/00006982-200112000-00003
PMID: 11756879
NLM abbreviation: Retina
ISSN: 0275-004X
eISSN: 1539-2864
Publisher: United States
Grant note: EY10539 / NEI NIH HHS
Language: English
Date published: 2001
Academic Unit: The University of Iowa Institute for Vision Research; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983979912202771

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