Journal article
Visual recovery in patients with Leber's hereditary optic neuropathy and the 11778 mutation
Journal of clinical neuro-ophthalmology, Vol.12(1), pp.10-14
03/1992
PMID: 1532593
Abstract
Five patients with Leber's hereditary optic neuropathy (LHON) and the 11778 mitochondrial mutation spontaneously recovered 20/40 or better visual acuity in at least one eye after months to years of legal blindness. The patients ranged in age from 9 to 45 years, and the duration of visual loss before recovery ranged from several months to 5.9 years. These patients constitute only about 4% of the 136 affected LHON patients we have studied who also had the 11778 mutation in their mitochondrial DNA. Thus, even though the visual prognosis for most patients with LHON and the 11778 mutation is poor, a few individuals do recover near-normal vision in at least one eye even years after the initial visual loss.
Details
- Title: Subtitle
- Visual recovery in patients with Leber's hereditary optic neuropathy and the 11778 mutation
- Creators
- E M Stone - Department of Ophthalmology, University of Iowa College of Medicine, Iowa CityN J NewmanN R MillerD R JohnsM T LottD C Wallace
- Resource Type
- Journal article
- Publication Details
- Journal of clinical neuro-ophthalmology, Vol.12(1), pp.10-14
- PMID
- 1532593
- NLM abbreviation
- J Clin Neuroophthalmol
- ISSN
- 0272-846X
- Publisher
- United States
- Grant note
- N521328 / PHS HHS EY08426 / NEI NIH HHS
- Language
- English
- Date published
- 03/1992
- Academic Unit
- Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980007102771
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