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Visualizing neuromodulation in vivo: TANGO-mapping of dopamine signaling reveals appetite control of sugar sensing
Journal article   Open access   Peer reviewed

Visualizing neuromodulation in vivo: TANGO-mapping of dopamine signaling reveals appetite control of sugar sensing

Hidehiko K Inagaki, Shlomo Ben-Tabou de-Leon, Allan M Wong, Smitha Jagadish, Hiroshi Ishimoto, Gilad Barnea, Toshihiro Kitamoto, Richard Axel and David J Anderson
Cell (Cambridge), Vol.148(3), pp.583-595
02/03/2012
DOI: 10.1016/j.cell.2011.12.022
PMCID: PMC3295637
PMID: 22304923
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https://doi.org/10.1016/j.cell.2011.12.022View
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Abstract

Behavior cannot be predicted from a "connectome" because the brain contains a chemical "map" of neuromodulation superimposed upon its synaptic connectivity map. Neuromodulation changes how neural circuits process information in different states, such as hunger or arousal. Here we describe a genetically based method to map, in an unbiased and brain-wide manner, sites of neuromodulation under different conditions in the Drosophila brain. This method, and genetic perturbations, reveal that the well-known effect of hunger to enhance behavioral sensitivity to sugar is mediated, at least in part, by the release of dopamine onto primary gustatory sensory neurons, which enhances sugar-evoked calcium influx. These data reinforce the concept that sensory neurons constitute an important locus for state-dependent gain control of behavior and introduce a methodology that can be extended to other neuromodulators and model organisms.
 Signal Transduction Drosophila melanogaster - physiology Receptors, Dopamine - metabolism Neurotransmitter Agents - metabolism Feeding Behavior Brain Mapping - methods Brain - physiology Animals Appetite Regulation Female Sensory Receptor Cells - metabolism Arrestin - metabolism Dopamine - metabolism

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