Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection

Michael G. Brown; Ayotunde O. Dokun; Jonathan W. Heusel; Hamish R. C. Smith; Diana L. Beckman; Erika A. Blattenberger; Chad E. Dubbelde; Laurie R. Stone; Anthony A. Scalzo; Wayne M. Yokoyama

doi:10.1126/science.1060042

Back

Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection

Journal article

Peer reviewed

Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection

Michael G. Brown, Ayotunde O. Dokun, Jonathan W. Heusel, Hamish R. C. Smith, Diana L. Beckman, Erika A. Blattenberger, Chad E. Dubbelde, Laurie R. Stone, Anthony A. Scalzo and Wayne M. Yokoyama

Science (American Association for the Advancement of Science), Vol.292(5518), pp.934-937

05/04/2001

DOI: 10.1126/science.1060042

PMID: 11340207

View Online

Abstract

Natural killer (NK) cells are lymphocytes that can be distinguished from T and B cells through their involvement in innate immunity and their lack of rearranged antigen receptors. Although NK cells and their receptors were initially characterized in terms of tumor killing in vitro, we have determined that the NK cell activation receptor, Ly-49H, is critically involved in resistance to murine cytomegalovirus in vivo. Ly-49H requires an immunoreceptor tyrosine-based activation motif (ITAM)–containing transmembrane molecule for expression and signal transduction. Thus, NK cells use receptors functionally resembling ITAM-coupled T and B cell antigen receptors to provide vital innate host defense.

Details

Title: Subtitle: Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection
Creators: Michael G. Brown - Howard Hughes Medical Institute, Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110, USA
Ayotunde O. Dokun - Icahn School of Medicine at Mount Sinai
Jonathan W. Heusel - Howard Hughes Medical Institute
Hamish R. C. Smith - Howard Hughes Medical Institute
Diana L. Beckman - Howard Hughes Medical Institute
Erika A. Blattenberger - Howard Hughes Medical Institute
Chad E. Dubbelde - Howard Hughes Medical Institute
Laurie R. Stone - Howard Hughes Medical Institute
Anthony A. Scalzo - University of Western Australia
Wayne M. Yokoyama - Howard Hughes Medical Institute
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.292(5518), pp.934-937
DOI: 10.1126/science.1060042
PMID: 11340207
ISSN: 0036-8075
eISSN: 1095-9203
Language: English
Date published: 05/04/2001
Academic Unit: Molecular Physiology and Biophysics; Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984297608302771

Metrics

8 Record Views

508 Times Cited - Web of Science

See more details