Journal article
Vital Signs: Update on Zika Virus-Associated Birth Defects and Evaluation of All US Infants with Congenital Zika Virus Exposure - US Zika Pregnancy Registry, 2016
MMWR. Morbidity and mortality weekly report, Vol.66(13), pp.366-373
04/07/2017
DOI: 10.15585/mmwr.mm6613e1
PMCID: PMC5657905
PMID: 28384133
Abstract
Background: In collaboration with state, tribal, local, and territorial health departments, CDC established the U.S. Zika Pregnancy Registry (USZPR) in early 2016 to monitor pregnant women with laboratory evidence of possible recent Zika virus infection and their infants.
Methods: This report includes an analysis of completed pregnancies (which include live births and pregnancy losses, regardless of gestational age) in the 50 U.S. states and the District of Columbia (DC) with laboratory evidence of possible recent Zika virus infection reported to the USZPR from January 15 to December 27, 2016. Birth defects potentially associated with Zika virus infection during pregnancy include brain abnormalities and/or microcephaly, eye abnormalities, other consequences of central nervous system dysfunction, and neural tube defects and other early brain malformations.
Results: During the analysis period, 1,297 pregnant women in 44 states were reported to the USZPR. Zika virus-associated birth defects were reported for 51 (5%) of the 972 fetuses/infants from completed pregnancies with laboratory evidence of possible recent Zika virus infection (95% confidence interval [CI] = 4%-7%); the proportion was higher when restricted to pregnancies with laboratory-confirmed Zika virus infection (24/250 completed pregnancies [10%, 95% CI = 7%-14%]). Birth defects were reported in 15% (95% CI = 8%-26%) of fetuses/infants of completed pregnancies with confirmed Zika virus infection in the first trimester. Among 895 liveborn infants from pregnancies with possible recent Zika virus infection, postnatal neuroimaging was reported for 221 (25%), and Zika virus testing of at least one infant specimen was reported for 585 (65%).
Conclusions and Implications for Public Health Practice: These findings highlight why pregnant women should avoid Zika virus exposure. Because the full clinical spectrum of congenital Zika virus infection is not yet known, all infants born to women with laboratory evidence of possible recent Zika virus infection during pregnancy should receive postnatal neuroimaging and Zika virus testing in addition to a comprehensive newborn physical exam and hearing screen. Identification and follow-up care of infants born to women with laboratory evidence of possible recent Zika virus infection during pregnancy and infants with possible congenital Zika virus infection can ensure that appropriate clinical services are available.
Details
- Title: Subtitle
- Vital Signs: Update on Zika Virus-Associated Birth Defects and Evaluation of All US Infants with Congenital Zika Virus Exposure - US Zika Pregnancy Registry, 2016
- Creators
- Megan R. Reynolds - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USAAbbey M. Jones - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USAEmily E. Petersen - CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USAEllen H. Lee - New York City Dept Hlth & Mental Hyg, New York, NY USAMarion E. Rice - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USAAndrea Bingham - Florida Dept Hlth, Tallahassee, FL USASascha R. Ellington - CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USANicole Evert - Texas Dept State Hlth Serv, Austin, TX USASarah Reagan-Steiner - CDC, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USATitilope Oduyebo - CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USACatherine M. Brown - Massachusetts Dept Publ Hlth, Boston, MA USAStacey Martin - VectorNina Ahmad - New York State Dept Hlth, Albany, NY USAJulu Bhatnagar - CDC, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USAJennifer Macdonald - Virginia Dept Hlth, Richmond, VA USACarolyn Gould - VectorAnne D. Fine - New York City Dept Hlth & Mental Hyg, New York, NY USAKara D. Polen - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USAHeather Lake-Burger - Florida Dept Hlth, Tallahassee, FL USAChristina L. Hillard - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USANoemi Hall - Texas Dept State Hlth Serv, Austin, TX USAMahsa M. Yazdy - Massachusetts Dept Publ Hlth, Boston, MA USAKarnesha Slaughter - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USAJamie N. Sommer - New York State Dept Hlth, Albany, NY USAAlys Adamski - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USAMeghan RaycraftShannon Fleck-Derderian - Oak Ridge Inst Sci & Educ, Oak Ridge, TN USAJyoti Gupta - Virginia Dept Hlth, Richmond, VA USAKimberly Newsome - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USAMadelyn Baez-Santiago - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USASally Slavinski - New York City Dept Hlth & Mental Hyg, New York, NY USAJennifer L. White - New York State Dept Hlth, Albany, NY USACynthia A. Moore - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USACarrie K. Shapiro-Mendoza - CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USALyle Petersen - VectorColeen Boyle - CDC, Off Director, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USADenise J. Jamieson - CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USADana Meaney-Delman - CDC, Off Director, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USAMargaret A. Honein - CDC, Div Congenital & Dev Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USAUS Zika Pregnancy Registry
- Resource Type
- Journal article
- Publication Details
- MMWR. Morbidity and mortality weekly report, Vol.66(13), pp.366-373
- Publisher
- CENTERS DISEASE CONTROL
- DOI
- 10.15585/mmwr.mm6613e1
- PMID
- 28384133
- PMCID
- PMC5657905
- ISSN
- 0149-2195
- eISSN
- 1545-861X
- Number of pages
- 8
- Language
- English
- Date published
- 04/07/2017
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446427002771
Metrics
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