Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection

Cleia T Amaral; Núbia N Pontes; Bruna L L Maciel; Hugo S M Bezerra; Ana Nataly A B Triesta; Selma M B Jeronimo; Stephen E McGowan; Vera M Dantas

doi:10.1002/ppul.22621

Back

Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection

Journal article

Open access

Peer reviewed

Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection

Cleia T Amaral, Núbia N Pontes, Bruna L L Maciel, Hugo S M Bezerra, Ana Nataly A B Triesta, Selma M B Jeronimo, Stephen E McGowan and Vera M Dantas

Pediatric pulmonology, Vol.48(5), pp.481-489

05/2013

DOI: 10.1002/ppul.22621

PMCID: PMC7167945

PMID: 22833544

Files and links (1)

url

https://doi.org/10.1002/ppul.22621View

Published (Version of record) Open Access

Abstract

To assess whether vitamin A deficiency alters the recovery of total respiratory resistance (TRR) following acute upper respiratory tract infection (URI). This is a case control study of children, age 4-6 years and grouped as: URI, (n = 74), URI and wheezing, (URI-wheezing, n = 52), and healthy controls (n = 51). Vitamin A and total respiratory resistance (TRR) were assessed using the modified relative dose response (MRDR) and forced oscillometry, respectively. Children with URI and URI-wheezing had lower retinol, 32.4 ± 13.12 and 18.3 ± 6.83 µg/dl respectively, compared to controls, 56.9 ± 29.82 µg/dl (ANOVA, P < 0.001). The MRDR was elevated in children in the URI or URI-wheezing groups 0.066 ± 0.045 and 0.021 ± 0.021, respectively, compared to controls 0.007 ± 0.006 (ANOVA, P < 0.0001). The TRR in the URI and URI-wheezing groups differed from controls. During convalescence, the TRR failed to decline in the URI-group only when the MRDR was >0.06. In the URI-wheezing group, TRR declined independently of retinol and MRDR. Vitamin A contributes to preservation of airway function during and in recovery after upper respiratory infection in children.

Cross-Sectional Studies

Comorbidity

Humans

Child, Preschool

Male

Airway Resistance

Vitamin A - analysis

Respiratory Sounds - physiopathology

Case-Control Studies

Vitamin A Deficiency - epidemiology

Vitamin A Deficiency - physiopathology

Female

Respiratory Tract Infections - epidemiology

C-Reactive Protein - analysis

Respiratory Tract Infections - physiopathology

Child

Details

Title: Subtitle: Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection
Creators: Cleia T Amaral - Heriberto Bezerra Pediatric Hospital, Universidade Federal do Rio Grande do Norte, Natal, Brazil
Núbia N Pontes
Bruna L L Maciel
Hugo S M Bezerra
Ana Nataly A B Triesta
Selma M B Jeronimo
Stephen E McGowan
Vera M Dantas
Resource Type: Journal article
Publication Details: Pediatric pulmonology, Vol.48(5), pp.481-489
DOI: 10.1002/ppul.22621
PMID: 22833544
PMCID: PMC7167945
NLM abbreviation: Pediatr Pulmonol
ISSN: 8755-6863
eISSN: 1099-0496
Publisher: United States
Grant note: R03 TW001297 / FIC NIH HHS
Language: English
Date published: 05/2013
Academic Unit: International Programs; Internal Medicine
Record Identifier: 9983984519502771

Metrics

30 Record Views

7 Times Cited - Web of Science