Journal article
Vitamin A deficiency alters pulmonary parenchymal collagen and tissue mechanics
Respiratory Physiology & Neurobiology, Vol.156(3), pp.312-319
2007
DOI: 10.1016/j.resp.2006.11.008
PMID: 17161662
Abstract
The mechanical properties of the pulmonary parenchyma are strongly influenced by the collagen and elastic fibers that course through the alveolar interstitium and interconnect the bronchovascular bundles. Vitamin A deficiency (VAD) produces effacement and remodeling of the alveolar architecture, resulting in alternating areas of alveolar dilatation and collapse. To better understand the mechanical consequences and reversibility of this remodeling process, we have examined how the remodeling of collagen and elastic fibers correlates with the mechanical properties of the lung parenchyma in VAD rats. An oscillatory impulse was applied at different levels of stress on the fiber network and the tissue damping ( G), elastance ( H), hysteresivity ( G/ H, η) were analyzed. At a supra-physiological functional residual capacity, the lung parenchyma of VAD rats exhibited a lower G and H than Vitamin A sufficient (VAS) rats, which was accompanied by a significant decrease in the quantity of parenchymal collagen and collagen fibers. Retinoic acid (RA) administration restored the parenchymal collagen and mechanical properties.
Details
- Title: Subtitle
- Vitamin A deficiency alters pulmonary parenchymal collagen and tissue mechanics
- Creators
- S.E McGowan - Department of Veterans Affairs Research Service, University of Iowa Carver College of Medicine, United StatesA.J Holmes - Department of Veterans Affairs Research Service, University of Iowa Carver College of Medicine, United States
- Resource Type
- Journal article
- Publication Details
- Respiratory Physiology & Neurobiology, Vol.156(3), pp.312-319
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.resp.2006.11.008
- PMID
- 17161662
- ISSN
- 1569-9048
- eISSN
- 1878-1519
- Language
- English
- Date published
- 2007
- Academic Unit
- International Programs; Internal Medicine
- Record Identifier
- 9983984531402771
Metrics
26 Record Views