Journal article
Vitamin B6 Is Effective Therapy for Nausea and Vomiting of Pregnancy: A Randomized, Double-Blind Placebo-Controlled Study
Obstetrics and gynecology (New York. 1953), Vol.78(1), pp.33-36
07/1991
PMID: 2047064
Abstract
Fifty-nine women completed a randomized, double-blind placebo-controlled study of pyridoxine hydrochloride (vitamin B6) for the treatment of nausea and vomiting of pregnancy. Thirty-one patients received vitamin B6, 25-mg tablets orally every 8 hours for 72 hours, and 28 patients received placebo in the same regimen. Patients were categorized according to the presence of vomitingsevere nausea (score greater than 7) or mild to moderate nausea (score of 7 or less). The severity of nausea (as graded on a visual analogue scale of 1-10 cm) and the number of patients with vomiting over a 72-hour period were used to evaluate response to therapy. Twelve of 31 patients in the vitamin B6 group had a pre-treatment nausea score greater than 7 (severe) (mean 8.2 ± 0.8), as did ten of 28 patients in the placebo group (mean 8.7 ± 0.9) (not significant). Following therapy, there was a significant difference in the mean “difference in nausea” score (ie, baseline — post-therapy nausea) between patients with severe nausea receiving vitamin B6 (mean 4.3 ± 2.1) and placebo (mean 1.8 ± 2.2) (P<.01). In patients with mild to moderate nausea and in the group as a whole, no significant difference between treatment and placebo was observed. Fifteen of 31 vitamin B6-treated patients had vomiting before therapy, compared with ten of 28 in the placebo group (not significant). At the completion of 3 days of therapy, only eight of 31 patients in the vitamin B6 group had any vomiting, compared with 15 of 28 patients in the placebo group (P<.05). The adjusted odds ratio for emesis in the treatment versus placebo groups, stratified by the presence or absence of pre-treatment emesis, was 0.1156 (P<.005). In conclusion, the mean “difference in nausea” score in patients with severe nausea and the total number of patients with vomiting were significantly reduced following vitamin B6 therapy
Details
- Title: Subtitle
- Vitamin B6 Is Effective Therapy for Nausea and Vomiting of Pregnancy: A Randomized, Double-Blind Placebo-Controlled Study
- Creators
- VICKEN Sahakian - From the Department of Obstetrics and Gynecology. The University of Iowa College of Medicine, Iowa City, IowaDWIGHT RouseSUSAN SipesNANCY RoseJENNIFER Niebyl - University of Iowa, Obstetrics and Gynecology
- Resource Type
- Journal article
- Publication Details
- Obstetrics and gynecology (New York. 1953), Vol.78(1), pp.33-36
- Publisher
- The American College of Obstetricians and Gynecologists
- PMID
- 2047064
- ISSN
- 0029-7844
- eISSN
- 1873-233X
- Language
- English
- Date published
- 07/1991
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983557425902771
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