Journal article
Vitamin D Levels in Newly Diagnosed Breast Cancer Patients according to Tumor Sub-Types
Journal of dietary supplements, Vol.20(6), pp.926-938
11/02/2023
DOI: 10.1080/19390211.2022.2144582
PMID: 36373265
Abstract
Vitamin D is an important regulator of bone health. In addition, as a ligand for a nuclear receptor expressed in breast cancer cells, vitamin D exerts neoplasia modulating effects in breast cancer. However, despite extensive investigations, associations of vitamin D levels with breast cancer patient characteristics and disease sub-types are conflicting. A retrospective review of medical records of consecutive breast cancer patients treated and followed in a single cancer center was undertaken. All patients with 25-hydroxyvitamin D (25-OHD, the circulating form of vitamin D) measurements available within 3 months of their diagnosis and before the start of any systemic treatment were included. Characteristics of patients and tumors with sufficient levels of 25-OHD were compared with those of patients with 25-OHD insufficiency. Two hundred ninety-two patients were included in the study. Almost two-thirds of the patients were 25-OHD insufficient, defined as having 25-OHD levels below 75 nmol/L. Compared with the group of patients who were 25-OHD sufficient, patients with 25-OHD insufficiency were younger and more often obese. Tumors of patients with 25-OHD insufficiency were more often ductal, of higher grade, and ER negative. 25-OHD insufficiency is prevalent in breast cancer patients and even more prevalent in younger and obese patients. 25-OHD insufficiency is associated with cancers that have aggressive characteristics, including higher grade and ER negativity.
Details
- Title: Subtitle
- Vitamin D Levels in Newly Diagnosed Breast Cancer Patients according to Tumor Sub-Types
- Creators
- Christopher Rosso - Algoma UniversityNicolas Fera - Algoma UniversityNirosha J. Murugan - Algoma UniversityIoannis A. Voutsadakis - NOSM University
- Resource Type
- Journal article
- Publication Details
- Journal of dietary supplements, Vol.20(6), pp.926-938
- Publisher
- Taylor & Francis
- DOI
- 10.1080/19390211.2022.2144582
- PMID
- 36373265
- ISSN
- 1939-0211
- eISSN
- 1939-022X
- Number of pages
- 13
- Language
- English
- Date published
- 11/02/2023
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806607902771
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