Journal article
Vitamin D Toxicity: A 16-Year Retrospective Study at an Academic Medical Center
Laboratory medicine, Vol.49(2), pp.123-129
03/21/2018
DOI: 10.1093/labmed/lmx077
PMID: 29346630
Abstract
Abstract
Background
Interest in vitamin D has increased during the past 2 decades, with a corresponding increase in laboratory testing of 25-hydroxyvitamin D [25(OH)D]. The vast majority of specimens tested display normal or deficient levels of 25(OH)D; concentrations rarely fall in the potentially toxic range.
Methods
We performed a retrospective investigation of elevated 25(OH)D levels during a 16-year period at the University of Iowa Hospitals and Clinics (UIHC), a 734-bed tertiary-/quaternary-care academic medical center in the midwestern United States. Detailed medical-record review was performed for patients with serum/plasma 25(OH)D concentrations higher than 120 ng per mL.
Results
A total of 127,932 serum/plasma 25(OH)D measurements were performed on 73,779 unique patients. Of these patients, 780 (1.05%) had results that exceeded 80 ng per mL and 89 patients (0.12%) had results that exceeded 120 ng per mL. Only 4 patients showed symptoms of vitamin D toxicity. Three of these cases involved inadvertent misdosing of liquid formulations.
Conclusions
Symptomatic vitamin D toxicity is uncommon, and elevated levels of 25(OH)D do not strongly correlate with clinical symptoms or total serum/plasma calcium levels. Our study highlights the potential risks of the liquid formulation of vitamin D.
Details
- Title: Subtitle
- Vitamin D Toxicity: A 16-Year Retrospective Study at an Academic Medical Center
- Creators
- John P Lee - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IAMichael Tansey - Divisions of Pediatric Endocrinology, University of Iowa Stead Family Children’s Hospital, Iowa City, IAJennifer G Jetton - Divisions of Pediatric Nephrology, Dialysis, and Transplantation, University of Iowa Stead Family Children’s Hospital, Iowa City, IAMatthew D Krasowski - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Laboratory medicine, Vol.49(2), pp.123-129
- Publisher
- Oxford University Press; US
- DOI
- 10.1093/labmed/lmx077
- PMID
- 29346630
- ISSN
- 0007-5027
- eISSN
- 1943-7730
- Language
- English
- Date published
- 03/21/2018
- Academic Unit
- Endocrinology and Diabetes; Stead Family Department of Pediatrics; Pathology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984047725302771
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