Journal article
Vitamin D and assisted reproductive treatment outcome: A prospective cohort study
Reproductive health, Vol.16(1), 106
07/15/2019
DOI: 10.1186/s12978-019-0769-7
PMCID: PMC6631833
PMID: 31307482
Abstract
Background
Vitamin D deficiency has been associated with an increased risk of abnormal pregnancy implantation leading to obstetric complications such as pre-eclampsia and fetal growth restriction. However, the effect of vitamin D on reproductive treatment outcomes in couples undergoing assisted reproductive treatment is poorly understood. This study investigates the association between vitamin D and reproductive treatment outcomes in women undergoing assisted reproductive treatments?
Methods
A prospective cohort study conducted at a large tertiary teaching hospital, United Kingdom. Five hundred women undergoing assisted reproductive treatment were recruited between September 2013 and September 2015. All participants had their serum vitamin D measured and their reproductive treatment outcomes collated. Women were categorised in to three groups: vitamin D replete (> 75 nmol/L), insufficient (50-75 nmol/L) and deficient (< 50 nmol/L) according to Endocrine Society guidance. The primary outcome was live birth. Secondary outcomes included biochemical pregnancy, clinical pregnancy and pregnancy loss rates.
Results
Vitamin D deficiency was found in 53.2% (266/500) of participants and vitamin D insufficiency was found in 30.8% (154/500) of participants. Only 16% (80/500) of women were vitamin D replete. The live birth rates for vitamin D deficient, insufficient and replete women were 23.2% (57/246), 27.0% (38/141) and 37.7% (29/77) respectively (p = 0.04). The respective live birth rates for vitamin D deficient, insufficient and replete women were 24.3, 27.1, 34.4% after adjustment for key prognostic factors (p = 0.25).
Conclusions
Vitamin D deficiency and insufficiency are common in women undergoing assisted reproductive treatments. The crude live birth rate achieved in women undergoing assisted reproductive treatments are associated with serum vitamin D, although statistical significance is lost when adjusting for important prognostic variables. Vitamin D deficiency could be an important condition to treat in women considering fertility treatment. A research trial to investigate the benefits of vitamin D deficiency treatment would test this hypothesis.
Details
- Title: Subtitle
- Vitamin D and assisted reproductive treatment outcome: A prospective cohort study
- Creators
- Justin Chu - Birmingham Women’s and Children’s NHS Foundation TrustIoannis Gallos - University of BirminghamAurelio Tobias - Institute of Environmental Assessment and Water ResearchLynne Robinson - Birmingham Women’s and Children’s NHS Foundation TrustJackson Kirkman-Brown - Birmingham Women’s and Children’s NHS Foundation TrustRima Dhillon-Smith - University of BirminghamHoda Harb - University of BirminghamAbey Eapen - Birmingham Women’s and Children’s NHS Foundation TrustMadhurima Rajkhowa - Birmingham Women’s and Children’s NHS Foundation TrustArri Coomarasamy - Birmingham Women’s and Children’s NHS Foundation Trust
- Resource Type
- Journal article
- Publication Details
- Reproductive health, Vol.16(1), 106
- DOI
- 10.1186/s12978-019-0769-7
- PMID
- 31307482
- PMCID
- PMC6631833
- NLM abbreviation
- Reprod Health
- ISSN
- 1742-4755
- eISSN
- 1742-4755
- Grant note
- Research and Development Department at the Birmingham Women’s and Children’s NHS Foundation Trust REC 13/WM/0258 / Birmingham Women’s and Children’s NHS Foundation Trust Research and Development Department
- Language
- English
- Date published
- 07/15/2019
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9985164052002771
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