Vitamin D insufficiency is associated with an increased risk of early clinical failure in follicular lymphoma

S. I. Tracy; M. J. Maurer; T. E. Witzig; M. T. Drake; S. M. Ansell; G. S. Nowakowski; C. A. Thompson; D. J. Inwards; P. B. Johnston; I. N. Micallef; C. Allmer; W. R. Macon; G. J. Weiner; S. L. Slager; T. M. Habermann; B. K. Link; J. R. Cerhan

doi:10.1038/bcj.2017.70

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Vitamin D insufficiency is associated with an increased risk of early clinical failure in follicular lymphoma

Journal article

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Vitamin D insufficiency is associated with an increased risk of early clinical failure in follicular lymphoma

S. I. Tracy, M. J. Maurer, T. E. Witzig, M. T. Drake, S. M. Ansell, G. S. Nowakowski, C. A. Thompson, D. J. Inwards, P. B. Johnston, I. N. Micallef, …

Blood cancer journal (New York), Vol.7(8), pp.e595-e595

08/25/2017

DOI: 10.1038/bcj.2017.70

PMCID: PMC5596381

PMID: 28841207

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Abstract

We evaluated whether vitamin D insufficiency (VDI; 25(OH)D < 20 ng/ml) was associated with adverse outcomes among follicular lymphoma (FL) patients using an observational prospective cohort study of 642 FL patients enrolled from 2002-2012. The median age at diagnosis was 60 years. At a median follow-up of 59 months, 297 patients (46%) had an event (progression, treatment failure), 78 had died and 42 (6.5%) had a lymphoma-related death. VDI was associated with inferior event-free survival (EFS) at 12 months (EFS12, odds ratio (OR) = 2.05; 95% confidence interval (CI) 1.18-3.54), overall survival (OS, hazards ratio (HR) = 2.35; 95% CI 1.37-4.02), and lymphoma-specific survival (LSS, HR = 2.97; 95% CI 1.52-5.80) for the full cohort. Among patients treated with immunochemotherapy (IC), VDI was associated with inferior EFS12 (OR = 3.00; 95% CI 1.26-7.13), OS (HR = 2.86; 95% CI 1.39-5.85), and LSS (HR = 2.96; 95% CI 1.29-6.79). For observed patients, VDI was associated with inferior OS (HR = 2.85; 95% CI 1.20-6.76). For other therapies, VDI was associated with inferior OS (HR = 3.06; 95% CI 1.01-9.24). Our work is the first to reveal an association of VDI with early clinical failure, and to demonstrate an association of VDI with adverse outcomes among patients who are observed or treated with therapies other than IC. Our findings suggest a potentially modifiable prognostic factor to address in patients with FL.

Hematology

Oncology

Life Sciences & Biomedicine

Science & Technology

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Title: Subtitle: Vitamin D insufficiency is associated with an increased risk of early clinical failure in follicular lymphoma
Creators: S. I. Tracy - Mayo Clinic
M. J. Maurer - Mayo Clinic
T. E. Witzig - Mayo Clinic
M. T. Drake - Mayo Clinic
S. M. Ansell - Mayo Clinic
G. S. Nowakowski - Mayo Clinic
C. A. Thompson - Mayo Clinic
D. J. Inwards - Mayo Clinic
P. B. Johnston - Mayo Clinic
I. N. Micallef - Mayo Clinic
C. Allmer - Mayo Clinic
W. R. Macon - Mayo Clinic
G. J. Weiner - University of Iowa
S. L. Slager - Mayo Clinic
T. M. Habermann - Mayo Clinic
B. K. Link - University of Iowa
J. R. Cerhan - Division of Epidemiology/ Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
Resource Type: Journal article
Publication Details: Blood cancer journal (New York), Vol.7(8), pp.e595-e595
DOI: 10.1038/bcj.2017.70
PMID: 28841207
PMCID: PMC5596381
NLM abbreviation: Blood Cancer J
ISSN: 2044-5385
eISSN: 2044-5385
Publisher: Springer Nature
Number of pages: 7
Grant note: P50CA097274 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P50 CA97274 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Henry J. Predolin Foundation
Language: English
Date published: 08/25/2017
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Pharmaceutical Sciences and Experimental Therapeutics; Internal Medicine
Record Identifier: 9984359768102771

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