Journal article
Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations
The Journal of nutrition, Vol.143(1), pp.17-26
01/2013
DOI: 10.3945/jn.112.169482
PMCID: PMC3521459
PMID: 23190755
Abstract
Vitamin D deficiency {defined by the blood concentration of 25-hydroxyvitamin D [25(OH)D]} has been associated with many adverse health outcomes. Genetic and nongenetic factors account for variation in 25(OH)D, but the role of interactions between these factors is unknown. To assess this, we examined 1204 women of European descent from the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women's Health Initiative Observational Study. Twenty-nine single nucleotide polymorphisms (SNPs) in 4 genes, GC, CYP2R1, DHCR7, and CYP24A1, from recent meta-analyses of 25(OH)D genome-wide association studies were genotyped. Associations between these SNPs and 25(OH)D were tested using generalized linear regression under an additive genetic model adjusted for age, blood draw month, and ancestry. Results were stratified by season of blood draw and, separately, vitamin D intake for the 6 SNPs showing a significant association with 25(OH)D at the P < 0.01 level. Two nonsynonymous SNPs in GC and 4 SNPs in CYP2R1 were strongly associated with 25(OH)D in individuals whose blood was drawn in summer (P ≤ 0.002) but not winter months and, independently, in individuals with vitamin D intakes ≥400 (P ≤ 0.004) but not <400 IU/d (10 μg/d). This effect modification, if confirmed, has important implications for the design of genetic studies for all health outcomes and for public health recommendations and clinical practice guidelines regarding the achievement of adequate vitamin D status.
Details
- Title: Subtitle
- Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations
- Creators
- Corinne D Engelman - Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. cengelman@wisc.eduKristin J MeyersSudha K IyengarZhe LiuChitra K KarkiRobert P Igo JrBarbara TruittJennifer RobinsonGloria E SartoRobert WallaceBarbara A BlodiMichael L KleinLesley TinkerErin S LeBlancRebecca D JacksonYiqing SongJoAnn E MansonJulie A MaresAmy E Millen
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.143(1), pp.17-26
- DOI
- 10.3945/jn.112.169482
- PMID
- 23190755
- PMCID
- PMC3521459
- NLM abbreviation
- J Nutr
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Publisher
- United States
- Grant note
- EY016886 / NEI NIH HHS EY013018 / NEI NIH HHS
- Language
- English
- Date published
- 01/2013
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983996197102771
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