Journal article
Vitamin D receptor (VDR) and metabolizing enzymes CYP27B1 and CYP24A1 in breast cancer
Molecular biology reports, Vol.47(12), pp.9821-9830
12/01/2020
DOI: 10.1007/s11033-020-05780-1
PMID: 33259013
Abstract
Vitamin D Receptor (VDR), a nuclear steroid receptor, is a transcription factor with a primary physiologic role in calcium metabolism. It has also a physiologic role in breast tissues during development of the gland and postpartum. In addition, it is commonly expressed in breast cancer and has tumor suppressive effects. Cytochrome enzymes CYP27B1 and CYP24A1 that perform the final conversion of the circulating form of vitamin D, 25-hydroxyvitamin D (25-OHD) to the active VDR ligand, 1a,25-dihydroxyvitamin D and the catabolism of it to inactive 24,25-dihydroxyvitamin D, respectively, are also expressed in breast cancer tissues. Defective regulation of the receptor and the metabolic enzymes of VDR ligand is prevalent in breast cancer and leads to decreased VDR signaling. The expression and molecular defects of VDR, CYP27B1 and CYP24A1 that perturb physiologic function, the implications for breast cancer progression and therapeutic opportunities are discussed in this paper.
Details
- Title: Subtitle
- Vitamin D receptor (VDR) and metabolizing enzymes CYP27B1 and CYP24A1 in breast cancer
- Creators
- Ioannis A. Voutsadakis - Essar Steel Algoma
- Resource Type
- Journal article
- Publication Details
- Molecular biology reports, Vol.47(12), pp.9821-9830
- Publisher
- Springer Nature
- DOI
- 10.1007/s11033-020-05780-1
- PMID
- 33259013
- ISSN
- 0301-4851
- eISSN
- 1573-4978
- Number of pages
- 10
- Language
- English
- Date published
- 12/01/2020
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806511002771
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