Vitamin D status and early age-related macular degeneration in postmenopausal women

Amy E Millen; Rick Voland; Sherie A Sondel; Niyati Parekh; Ronald L Horst; Robert B Wallace; Gregory S Hageman; Rick Chappell; Barbara A Blodi; Michael L Klein; Karen M Gehrs; Gloria E Sarto; Julie A Mares; CAREDS Study Group

doi:10.1001/archophthalmol.2011.48

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Vitamin D status and early age-related macular degeneration in postmenopausal women

Journal article

Open access

Peer reviewed

Vitamin D status and early age-related macular degeneration in postmenopausal women

Amy E Millen, Rick Voland, Sherie A Sondel, Niyati Parekh, Ronald L Horst, Robert B Wallace, Gregory S Hageman, Rick Chappell, Barbara A Blodi, Michael L Klein, …

Archives of ophthalmology (1960), Vol.129(4), pp.481-489

04/2011

DOI: 10.1001/archophthalmol.2011.48

PMCID: PMC3075411

PMID: 21482873

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Abstract

The relationship between serum 25-hydroxyvitamin D (25[OH]D) concentrations (nmol/L) and the prevalence of early age-related macular degeneration (AMD) was investigated in participants of the Carotenoids in Age-Related Eye Disease Study. Stereoscopic fundus photographs, taken from 2001 to 2004, assessed AMD status. Baseline (1994-1998) serum samples were available for 25(OH)D assays in 1313 women with complete ocular and risk factor data. Odds ratios (ORs) and 95% confidence intervals (CIs) for early AMD (n = 241) of 1287 without advanced disease were estimated with logistic regression and adjusted for age, smoking, iris pigmentation, family history of AMD, cardiovascular disease, diabetes, and hormone therapy use. In multivariate models, no significant relationship was observed between early AMD and 25(OH)D (OR for quintile 5 vs 1, 0.79; 95% CI, 0.50-1.24; P for trend = .47). A significant age interaction (P = .002) suggested selective mortality bias in women aged 75 years and older: serum 25(OH)D was associated with decreased odds of early AMD in women younger than 75 years (n = 968) and increased odds in women aged 75 years or older (n = 319) (OR for quintile 5 vs 1, 0.52; 95% CI, 0.29-0.91; P for trend = .02 and OR, 1.76; 95% CI, 0.77-4.13; P for trend = .05, respectively). Further adjustment for body mass index and recreational physical activity, predictors of 25(OH)D, attenuated the observed association in women younger than 75 years. Additionally, among women younger than 75 years, intake of vitamin D from foods and supplements was related to decreased odds of early AMD in multivariate models; no relationship was observed with self-reported time spent in direct sunlight. High serum 25(OH)D concentrations may protect against early AMD in women younger than 75 years.

Macular Degeneration - prevention & control

Postmenopause - blood

Prevalence

Humans

Middle Aged

Risk Factors

Feeding Behavior

Macular Degeneration - blood

Vitamin D - blood

Diet

Macular Degeneration - epidemiology

Sunlight

Female

Surveys and Questionnaires

Vitamin D - analogs & derivatives

Aged

Odds Ratio

Dietary Supplements

Details

Title: Subtitle: Vitamin D status and early age-related macular degeneration in postmenopausal women
Creators: Amy E Millen - Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY 14214, USA. aemillen@buffal.edu
Rick Voland
Sherie A Sondel
Niyati Parekh
Ronald L Horst
Robert B Wallace
Gregory S Hageman
Rick Chappell
Barbara A Blodi
Michael L Klein
Karen M Gehrs
Gloria E Sarto
Julie A Mares
CAREDS Study Group
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.129(4), pp.481-489
DOI: 10.1001/archophthalmol.2011.48
PMID: 21482873
PMCID: PMC3075411
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association; United States
Grant note: N01WH42132 / WHI NIH HHS EY016886 / NEI NIH HHS N01WH42114 / WHI NIH HHS U10 EY013018-03 / NEI NIH HHS N01WH32115 / WHI NIH HHS N01WH32102 / WHI NIH HHS P30 EY014800-07 / NEI NIH HHS N01WH24152 / WHI NIH HHS U10 EY013018 / NEI NIH HHS U10 EY013018-05 / NEI NIH HHS N01WH42117 / WHI NIH HHS N01WH44221 / WHI NIH HHS N01WH32105 / WHI NIH HHS N01WH32118 / WHI NIH HHS N01WH42122 / WHI NIH HHS N01WH42130 / WHI NIH HHS P30 EY014800 / NEI NIH HHS N01WH42112 / WHI NIH HHS N01WH42129 / WHI NIH HHS N01WH32122 / WHI NIH HHS N01WH32113 / WHI NIH HHS N01WH42121 / WHI NIH HHS N01WH42115 / WHI NIH HHS N01WH42124 / WHI NIH HHS N01WH42109 / WHI NIH HHS N01WH42123 / WHI NIH HHS N01WH32111 / WHI NIH HHS U10 EY013018-04 / NEI NIH HHS N01WH42118 / WHI NIH HHS R01 EY016886 / NEI NIH HHS N01WH42110 / WHI NIH HHS N01WH32106 / WHI NIH HHS N01WH32119 / WHI NIH HHS N01WH32101 / WHI NIH HHS DK07665 / NIDDK NIH HHS N01WH42131 / WHI NIH HHS N01WH42108 / WHI NIH HHS N01WH42126 / WHI NIH HHS N01WH42113 / WHI NIH HHS EY13018 / NEI NIH HHS N01WH32109 / WHI NIH HHS U10 EY013018-02 / NEI NIH HHS N01WH42107 / WHI NIH HHS N01WH42125 / WHI NIH HHS N01WH42116 / WHI NIH HHS N01WH32108 / WHI NIH HHS U10 EY013018-01 / NEI NIH HHS N01WH32100 / WHI NIH HHS N01WH32112 / WHI NIH HHS N01WH42119 / WHI NIH HHS N01WH22110 / WHI NIH HHS N01WH42111 / WHI NIH HHS N01WH42120 / WHI NIH HHS
Language: English
Date published: 04/2011
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine; Ophthalmology and Visual Sciences
Record Identifier: 9983979914802771

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