Journal article
Vitamin K Deficiency Is Associated with Incident Knee Osteoarthritis
The American journal of medicine, Vol.126(3), pp.243-248
03/2013
DOI: 10.1016/j.amjmed.2012.10.011
PMCID: PMC3641753
PMID: 23410565
Abstract
Osteoarthritis is the most common form of arthritis, with knee osteoarthritis being the leading cause of lower extremity disability among older adults in the US. There are no treatments available to prevent the structural pathology of osteoarthritis. Because of vitamin K's role in regulating skeletal mineralization, it has potential to be a preventative option for osteoarthritis. We therefore examined the relation of vitamin K to new-onset radiographic knee osteoarthritis and early osteoarthritis changes on magnetic resonance imaging (MRI).
Subjects from the Multicenter Osteoarthritis (MOST) Study had knee radiographs and MRI scans obtained at baseline and 30 months later, and plasma phylloquinone (vitamin K) measured at baseline. We examined the relationship of subclinical vitamin K deficiency to incident radiographic knee osteoarthritis and MRI-based cartilage lesions and osteophytes, respectively, using log binomial regression with generalized estimating equations, adjusting for potential confounders.
Among 1180 participants (62% women, mean age 62±8 years, mean body mass index 30.1±5.1 kg/m2), subclinical vitamin K deficiency was associated with incident radiographic knee osteoarthritis (risk ratio [RR] 1.56; 95% confidence interval [CI], 1.08-2.25) and cartilage lesions (RR 2.39; 95% CI, 1.05-5.40) compared with no deficiency, but not with osteophytes (RR 2.35; 95% CI, 0.54-10.13). Subclinically vitamin K-deficient subjects were more likely to develop osteoarthritis in one or both knees than neither knee (RR 1.33; 95% CI, 1.01-1.75 and RR 2.12; 95% CI, 1.06-4.24, respectively).
In the first such longitudinal study, subclinical vitamin K deficiency was associated with increased risk of developing radiographic knee osteoarthritis and MRI-based cartilage lesions. Further study of vitamin K is warranted given its therapeutic/prophylactic potential for osteoarthritis.
Details
- Title: Subtitle
- Vitamin K Deficiency Is Associated with Incident Knee Osteoarthritis
- Creators
- Devyani Misra - Boston University School of Medicine, MassSarah L Booth - US Department of Agriculture, Human Nutrition Research Center for Aging, Tufts University, Boston, MassIrina Tolstykh - University of California at San FranciscoDavid T Felson - Boston University School of Medicine, MassMichael C Nevitt - University of California at San FranciscoCora E Lewis - University of Alabama at BirminghamJames Torner - University of Iowa, Iowa CityTuhina Neogi - Boston University School of Medicine, Mass
- Resource Type
- Journal article
- Publication Details
- The American journal of medicine, Vol.126(3), pp.243-248
- DOI
- 10.1016/j.amjmed.2012.10.011
- PMID
- 23410565
- PMCID
- PMC3641753
- NLM abbreviation
- Am J Med
- ISSN
- 0002-9343
- eISSN
- 1555-7162
- Publisher
- Elsevier Inc
- Grant note
- K23 AR055127 / NIAMS U01-AG18820; U01-AG19069; U01-AG18947; U01-AG18832 / NIA AG14759; HL696272 / National Institutes of Health AR47785 / NIH
- Language
- English
- Date published
- 03/2013
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983996092902771
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