Vocalization development in common marmosets for neurodegenerative translational modeling

Corinne A Jones; Mary K Duffy; Sarah A Hoffman; Nancy J Schultz-Darken; Katarina M Braun; Michelle R Ciucci; Marina E Emborg

doi:10.1080/01616412.2018.1438226

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Vocalization development in common marmosets for neurodegenerative translational modeling

Journal article

Peer reviewed

Vocalization development in common marmosets for neurodegenerative translational modeling

Corinne A Jones, Mary K Duffy, Sarah A Hoffman, Nancy J Schultz-Darken, Katarina M Braun, Michelle R Ciucci and Marina E Emborg

Neurological research (New York), Vol.40(4), pp.303-311

04/03/2018

DOI: 10.1080/01616412.2018.1438226

PMID: 29457539

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Abstract

Objectives In order to facilitate the study of vocalizations in emerging genetic common marmoset models of neurodegenerative disorders, we aimed to analyze call-type changes across age in a translational research environment. We hypothesized that acoustic parameters of vocalizations would change with age, reflecting growth of the vocal apparatus and a maturation of control needed to make adult-like calls. Methods Nineteen developing common marmosets were longitudinally video- and audio-recorded between the ages of 1-149 days in a naturalistic setting without any vocalization elicitation protocol. Vocalizations were coded for call type (cry, tsik, trill, phee, and trill-phee) and analyzed for duration (sec), minimum and maximum frequency (Hz), and bandwidth (Hz). Mixed model linear regressions were performed to assess the effects of age on call parameters listed above for each call type. Results Cries decreased in duration (P = 0.038), maximum frequency (P = 0.047), and bandwidth (P = 0.023) with age. Tsik calls decreased in duration (P = 0.002) and increased in minimum frequency (P = 0.004) and maximum frequency (P = 0.005) with age. Trill calls increased in duration (P = 0.003), and trillphee bandwidth (P = 0.031) decreased with age. Discussion Our results demonstrate that development of common marmoset vocalizations is call type dependent and that changes in acoustic parameters can be detected without complex vocalization elicitation paradigms or specialized audio recording equipment. Thus, we demonstrate the feasibility of a naturalistic protocol to collect and objectively analyze marmoset vocalizations longitudinally. This approach may be useful for studying vocal communication deficits in genetic models of neurodegenerative disorders.

Animals

Callithrix

Disease Models, Animal

Female

Male

Neurodegenerative Diseases - psychology

Sound Spectrography

Translational Research, Biomedical

Vocalization, Animal

Details

Title: Subtitle: Vocalization development in common marmosets for neurodegenerative translational modeling
Creators: Corinne A Jones - University of Wisconsin–Madison
Mary K Duffy - University of Wisconsin–Madison
Sarah A Hoffman - University of Wisconsin–Madison
Nancy J Schultz-Darken - University of Wisconsin–Madison
Katarina M Braun - University of Wisconsin–Madison
Michelle R Ciucci - University of Wisconsin–Madison
Marina E Emborg - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Neurological research (New York), Vol.40(4), pp.303-311
DOI: 10.1080/01616412.2018.1438226
PMID: 29457539
ISSN: 0161-6412
eISSN: 1743-1328
Grant note: R24 OD019803 / NIH HHS T32 GM007507 / NIGMS NIH HHS P51 OD011106 / NIH HHS F31 DC015706 / NIDCD NIH HHS R01 DC014358 / NIDCD NIH HHS R21 DC011130 / NIDCD NIH HHS
Language: English
Date published: 04/03/2018
Academic Unit: Communication Sciences and Disorders
Record Identifier: 9985217029902771

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