Journal article
Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
Molecular psychiatry, Vol.28(3), pp.1079-1089
03/01/2023
DOI: 10.1038/s41380-022-01933-9
PMCID: PMC10804423
PMID: 36653677
Abstract
There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, p
= 0.037; right: d = -0.104, p
= 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, p
= 0.045). Smaller bilateral putamen volumes (left: d = -0.141, p
< 0.001; right: d = -0.158, p
< 0.001) and larger bilateral pallidum volumes (left: d = 0.129, p
= 0.006; right: d = 0.099, p
= 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adulthood.
Details
- Title: Subtitle
- Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
- Creators
- Nynke A Groenewold - University of Cape TownJanna Marie Bas-Hoogendam - Leiden UniversityAlyssa R Amod - University of Cape TownMax A Laansma - Amsterdam NeuroscienceLaura S Van Velzen - The University of MelbourneMoji Aghajani - Leiden UniversityKevin Hilbert - Humboldt-Universität zu BerlinHyuntaek Oh - Baylor College of MedicineRamiro Salas - Michael E. DeBakey VA Medical CenterAndrea P Jackowski - Universidade Federal de São PauloPedro M Pan - Universidade Federal de São PauloGiovanni A Salum - Universidade Federal do Rio Grande do SulJames R Blair - Mental Health ServicesKarina S Blair - Boys TownJoy Hirsch - Yale UniversitySpiro P Pantazatos - Columbia University Irving Medical CenterFranklin R Schneier - Columbia University Irving Medical CenterArdesheer Talati - Columbia University Irving Medical CenterKarin Roelofs - Radboud University NijmegenInge Volman - John Radcliffe HospitalLaura Blanco-Hinojo - Centro de Investigación Biomédica en Red de Salud MentalNarcís Cardoner - Universitat Autònoma de BarcelonaJesus Pujol - Centro de Investigación Biomédica en Red de Salud MentalKatja Beesdo-Baum - Technische Universität DresdenChristopher R K Ching - University of Southern CaliforniaSophia I Thomopoulos - University of Southern CaliforniaAndreas Jansen - Philipps University of MarburgTilo Kircher - Philipps University of MarburgAxel Krug - Philipps University of MarburgIgor Nenadić - Philipps University of MarburgFrederike Stein - Philipps University of MarburgUdo Dannlowski - University of MünsterDominik Grotegerd - University of MünsterHannah Lemke - University of MünsterSusanne Meinert - University of MünsterAlexandra Winter - University of MünsterMichael Erb - University of TübingenBenjamin Kreifelts - University of TübingenQiyong Gong - Sichuan UniversitySu Lui - Chinese Academy of Medical Sciences & Peking Union Medical CollegeFei Zhu - Chinese Academy of Medical Sciences & Peking Union Medical CollegeBenson Mwangi - The University of Texas Health Science Center at HoustonJair C Soares - The University of Texas Health Science Center at HoustonMon-Ju Wu - The University of Texas Health Science Center at HoustonAli Bayram - Istanbul UniversityMesut Canli - Istanbul UniversityRaşit Tükel - Istanbul UniversityP Michiel Westenberg - Leiden UniversityAlexandre Heeren - UCLouvainHenk R Cremers - University of AmsterdamDavid Hofmann - University of MünsterThomas Straube - University of MünsterAlexander G G Doruyter - Division of Nuclear Medicine, Stellenbosch University, Stellenbosch, South AfricaChristine Lochner - Stellenbosch UniversityJutta Peterburs - MSH Medical School Hamburg – University of Applied Sciences and Medical UniversityMarie-José Van Tol - University Medical Center GroningenRaquel E Gur - University of PennsylvaniaAntonia N Kaczkurkin - Vanderbilt UniversityBart Larsen - University of PennsylvaniaTheodore D Satterthwaite - University of PennsylvaniaCourtney A Filippi - National Institutes of HealthAndrea L Gold - Brown UniversityAnita Harrewijn - National Institutes of HealthAndré Zugman - National Institutes of HealthRobin Bülow - Universitätsmedizin GreifswaldHans J Grabe - Universitätsmedizin GreifswaldHenry Völzke - Universitätsmedizin GreifswaldKatharina Wittfeld - Universitätsmedizin GreifswaldJoscha Böhnlein - University of MünsterKatharina Dohm - University of MünsterHarald Kugel - University of MünsterElisabeth Schrammen - University of MünsterPeter Zwanzger - Inn-Salzach-KlinikumElisabeth J Leehr - University of MünsterLisa Sindermann - University of BonnTali M Ball - Stanford UniversityGregory A Fonzo - The University of Texas at AustinMartin P Paulus - Laureate Institute for Brain ResearchAlan Simmons - University of California San DiegoMurray B Stein - University of California San DiegoHeide Klumpp - University of Illinois ChicagoK Luan Phan - The Ohio State UniversityTomas Furmark - Uppsala UniversityKristoffer N T Månsson - Karolinska InstitutetAmirhossein Manzouri - Karolinska InstitutetSuzanne N Avery - Vanderbilt University Medical CenterJennifer Urbano Blackford - Nebraska Medical CenterJacqueline A Clauss - Harvard UniversityBrandee Feola - Vanderbilt University Medical CenterJennifer C Harper - Washington University in St. LouisChad M Sylvester - Washington University in St. LouisUlrike Lueken - Humboldt-Universität zu BerlinDick J Veltman - Amsterdam University Medical CentersAnderson M Winkler - National Institutes of HealthNeda Jahanshad - University of Southern CaliforniaDaniel S Pine - National Institutes of HealthPaul M Thompson - University of Southern CaliforniaDan J Stein - South African Medical Research CouncilNic J A Van der Wee - Leiden University Medical Center
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.28(3), pp.1079-1089
- DOI
- 10.1038/s41380-022-01933-9
- PMID
- 36653677
- PMCID
- PMC10804423
- NLM abbreviation
- Mol Psychiatry
- ISSN
- 1359-4184
- eISSN
- 1476-5578
- Grant note
- Z01 MH002781 / Intramural NIH HHS ZIA MH002781 / Intramural NIH HHS R01 MH129832 / NIMH NIH HHS U54 EB020403 / NIBIB NIH HHS T32 MH112485 / NIMH NIH HHS K23 MH109983 / NIMH NIH HHS T32 MH018921 / NIMH NIH HHS R01 MH065413 / NIMH NIH HHS I01 CX001937 / CSRD VA R01 MH122389 / NIMH NIH HHS
- Language
- English
- Date published
- 03/01/2023
- Academic Unit
- Psychiatry
- Record Identifier
- 9985222826302771
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