Journal article
Volume of the pineal gland in schizophrenia; an MRI study
Schizophrenia research, Vol.14(3), pp.253-255
1995
DOI: 10.1016/0920-9964(94)00077-L
PMID: 7766537
Abstract
Pineal gland abnormality has been proposed as a possible biological defect in schizophrenia. This study was designed to investigate volumetric differences of the pineal gland using Magnetic Resonance Imaging (MRI). Patients with a DSM-111-R diagnosis of schizophrenia or schizophreniform disorder (
n=45) and normal controls (
n=86) were scanned using a 1.5 Tesla scanner. The volume of the pineal was obtained by blind manual tracing of the gland on T1 weighted images, using locally developed software, BRAINS. The inter-rater reliability (
n=25) yielded an intraclass
r of 0.92. Comparison of the volumes by
t-test showed no significant difference between patients and normal controls (
p=0.77). This study, backed by a large sample size, suggests that there are no volumetric differences between schizophrenic patients and controls in regard to the pineal gland.
Details
- Title: Subtitle
- Volume of the pineal gland in schizophrenia; an MRI study
- Creators
- Rajaprabhakaran RajarethinamSanjay GuptaNancy C Andreasen
- Resource Type
- Journal article
- Publication Details
- Schizophrenia research, Vol.14(3), pp.253-255
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0920-9964(94)00077-L
- PMID
- 7766537
- ISSN
- 0920-9964
- eISSN
- 1573-2509
- Language
- English
- Date published
- 1995
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003959002771
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