Journal article
Volumetric Topological Analysis: A Novel Approach for Trabecular Bone Classification on the Continuum between Plates and Rods
IEEE transactions on medical imaging, Vol.29(11), pp.1821-1838
11/2010
DOI: 10.1109/TMI.2010.2050779
PMCID: PMC3113685
PMID: 20562041
Abstract
Trabecular bone (
TB
) is a complex quasi-random network of interconnected plates and rods. TB constantly remodels to adapt to the stresses to which it is subjected (Wolff s Law). In osteoporosis, this dynamic equilibrium between bone formation and resorption is perturbed, leading to bone loss and structural deterioration, both increasing fracture risk. Bone s mechanical behavior can only be partially explained by variations in bone mineral density, which led to the notion of bone structural quality. Previously, we developed digital topological analysis (
DTA
) which classifies plates, rods, profiles, edges, and junctions in a TB skeletal representation. Although the method has become quite popular, a major limitation of DTA is that it provides only hard classifications of different topological entities, failing to distinguish between narrow and wide plates. Here, we present a new method called volumetric topological analysis (
VTA
) for regional quantification of TB topology. At each TB location, the method uniquely classifies its topology on the continuum between perfect plates and perfect rods, facilitating early detections of TB alterations from plates to rods according to the known etiology of osteoporotic bone loss. Several new ideas, including manifold distance transform, manifold scale, and feature propagation have been introduced here and combined with existing DTA and distance transform methods, leading to the new VTA technology. This method has been applied to multi-detector CT and μCT images of four cadaveric distal tibia and five distal radius specimens. Both intra- and inter-modality reproducibility of the method has been examined using repeat CT and μCT scans of distal tibia specimens. Also, the method s ability to predict experimental biomechanical properties of TB via CT imaging under
in vivo
conditions has been quantitatively examined and the results found are very encouraging.
Details
- Title: Subtitle
- Volumetric Topological Analysis: A Novel Approach for Trabecular Bone Classification on the Continuum between Plates and Rods
- Creators
- Punam K Saha - Departments of Electrical and Computer Engineering and Radiology, University of Iowa, Iowa City, IA 52242Yan Xu - Departments of Electrical and Computer Engineering and Radiology, University of Iowa, Iowa City, IA 52242Hong Duan - Departments of Electrical and Computer Engineering and Radiology, University of Iowa, Iowa City, IA 52242Anneliese Heiner - Departments of Orthopaedics and Rehabilitation and Biomedical Engineering, University of Iowa, Iowa City, IA 52242Guoyuan Liang - Departments of Electrical and Computer Engineering and Radiology, University of Iowa, Iowa City, IA 52242
- Resource Type
- Journal article
- Publication Details
- IEEE transactions on medical imaging, Vol.29(11), pp.1821-1838
- DOI
- 10.1109/TMI.2010.2050779
- PMID
- 20562041
- PMCID
- PMC3113685
- NLM abbreviation
- IEEE Trans Med Imaging
- ISSN
- 0278-0062
- eISSN
- 1558-254X
- Publisher
- Institute of Electrical and Electronics Engineers
- Grant note
- R01 AR054439-02 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS R01 AR054439-03 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS
- Language
- English
- Date published
- 11/2010
- Academic Unit
- Radiology; Electrical and Computer Engineering
- Record Identifier
- 9984051502802771
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