Journal article
Volumetric additive manufacturing of pristine silk-based (bio)inks
Nature communications, Vol.14(1), 210
01/13/2023
DOI: 10.1038/s41467-023-35807-7
PMCID: PMC9839706
PMID: 36639727
Abstract
Volumetric additive manufacturing (VAM) enables fast photopolymerization of three-dimensional constructs by illuminating dynamically evolving light patterns in the entire build volume. However, the lack of bioinks suitable for VAM is a critical limitation. This study reports rapid volumetric (bio)printing of pristine, unmodified silk-based (silk sericin (SS) and silk fibroin (SF)) (bio)inks to form sophisticated shapes and architectures. Of interest, combined with post-fabrication processing, the (bio)printed SS constructs reveal properties including reversible as well as repeated shrinkage and expansion, or shape-memory; whereas the (bio)printed SF constructs exhibit tunable mechanical performances ranging from a few hundred Pa to hundreds of MPa. Both types of silk-based (bio)inks are cytocompatible. This work supplies expanded bioink libraries for VAM and provides a path forward for rapid volumetric manufacturing of silk constructs, towards broadened biomedical applications.
Details
- Title: Subtitle
- Volumetric additive manufacturing of pristine silk-based (bio)inks
- Creators
- Maobin XieLiming Lian - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USAXuan MuZeyu Luo - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USACarlos Ezio Garciamendez-Mijares - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USAZhenrui Zhang - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USAArturo Lopez - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USAJennifer Manriquez - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USAXiao Kuang - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USAJunqi Wu - Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USAJugal Kishore Sahoo - Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USAFederico Zertuche González - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USAGang Li - Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USAGuosheng Tang - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USASushila Maharjan - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USAJie Guo - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USADavid L Kaplan - Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USAYu Shrike Zhang - Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA. yszhang@research.bwh.harvard.edu
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.14(1), 210
- DOI
- 10.1038/s41467-023-35807-7
- PMID
- 36639727
- PMCID
- PMC9839706
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Grant note
- DOI: 10.13039/100000001, name: National Science Foundation, award: 1541959; DOI: 10.13039/100000009, name: Foundation for the National Institutes of Health, award: P41EB027062, R01AR070975; DOI: 10.13039/100008552, name: BWH | Brigham Research Institute
- Language
- English
- Date published
- 01/13/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984363947702771
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