Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II

Jerome J Maller; Prasanthan Thaveenthiran; Richard H Thomson; Susan McQueen; Paul B Fitzgerald

doi:10.1016/j.jad.2014.08.016

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Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II

Journal article

Peer reviewed

Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II

Jerome J Maller, Prasanthan Thaveenthiran, Richard H Thomson, Susan McQueen and Paul B Fitzgerald

Journal of affective disorders, Vol.169, pp.118-127

12/01/2014

DOI: 10.1016/j.jad.2014.08.016

PMID: 25189991

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Abstract

Bipolar disorder (BD) is a debilitating psychiatric disorder affecting millions of people worldwide with mean time to diagnosis estimated to be at least 10 years. Whilst many brain imaging studies have compared those with BD to controls, few have attempted to investigate differences between BD Type I and II and matched controls. Thirty-one patients with BD (16 Type I and 15 Type II) and 31 matched healthy controls were MRI brain scanned with conventional T1-weighted and diffusion tensor imaging methods. There was significantly reduced regional brain volume and thickness among the BD subjects, but also between BD Type I when compared to Type II. White matter integrity also differed between the groups and BD severity correlated significantly with regional brain volume and thickness. Future investigations will consider length of time each BD patient had been diagnosed with BD, as well as assessing controls for family history of psychiatric illness, specifically BD. Similarly, genetic assessment will be conducted as well. These findings suggest that there are not only regional brain volumetric, thickness and white matter integrity differences between BD and matched controls, but also between those with BD Type I and Type II, such that reduced regional brain volume may underlie BD Type I whereas white matter integrity is more altered in BD Type II.

Adult

Bipolar Disorder - pathology

Case-Control Studies

Cerebral Cortex - pathology

Diffusion Tensor Imaging

Female

Humans

Male

Middle Aged

Organ Size

White Matter - pathology

Details

Title: Subtitle: Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II
Creators: Jerome J Maller - Monash Alfred Psychiatry Research centre
Prasanthan Thaveenthiran - Monash Alfred Psychiatry Research centre
Richard H Thomson - The Alfred Hospital
Susan McQueen - Monash Alfred Psychiatry Research centre
Paul B Fitzgerald - Monash Alfred Psychiatry Research centre
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.169, pp.118-127
DOI: 10.1016/j.jad.2014.08.016
PMID: 25189991
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Language: English
Date published: 12/01/2014
Academic Unit: Radiology
Record Identifier: 9984848422802771

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