Journal article
Volumetric effects of motor cortex injury on recovery of dexterous movements
Experimental neurology, Vol.220(1), pp.90-108
2009
DOI: 10.1016/j.expneurol.2009.07.034
PMCID: PMC2778269
PMID: 19679127
Abstract
Due to the heterogeneous nature of most brain injuries, the contributions of gray and white matter involvement to motor deficits and recovery potential remain obscure. We tested the hypothesis that duration of hand motor impairment and recovery of skilled arm and hand motor function depends on the volume of gray and white matter damage of the frontal lobe. Lesions of the primary motor cortex (M1), M1 + lateral premotor cortex (LPMC), M1 + LPMC + supplementary motor cortex (M2) or multifocal lesions affecting motor areas and medial prefrontal cortex were evaluated in rhesus monkeys. Fine hand motor function was quantitatively assessed pre-lesion and for 3–12 months post-lesion using two motor tests. White and gray matter lesion volumes were determined using histological and quantitative methods. Regression analyses showed that duration of fine hand motor impairment was strongly correlated (
R
2
>
0.8) with the volume of gray and white matter lesions, with white matter lesion volume being the primary predictor of impairment duration. Level of recovery of fine hand motor skill was also well correlated (
R
2
>
0.5) with gray and white matter lesion volume. In some monkeys post-lesion skill exceeded pre-lesion skill in one or both motor tasks demonstrating that continued post-injury task practice can improve motor performance after localized loss of frontal motor cortex. These findings will assist in interpreting acute motor deficits, predicting the time course and expected level of functional recovery, and designing therapeutic strategies in patients with localized frontal lobe injury or neurosurgical resection.
Details
- Title: Subtitle
- Volumetric effects of motor cortex injury on recovery of dexterous movements
- Creators
- Warren G Darling - Department of Integrative Physiology, Motor Performance Laboratory, The University of Iowa, Iowa City, IA 52242, USAMarc A Pizzimenti - Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USADiane L Rotella - Department of Integrative Physiology, Motor Performance Laboratory, The University of Iowa, Iowa City, IA 52242, USAClayton R Peterson - Department of Integrative Physiology, Motor Performance Laboratory, The University of Iowa, Iowa City, IA 52242, USAStephanie M Hynes - Department of Integrative Physiology, Motor Performance Laboratory, The University of Iowa, Iowa City, IA 52242, USAJizhi Ge - Division of Basic Biomedical Sciences, Laboratory of Neurological Sciences, The University of South Dakota, Sanford School of Medicine, Vermillion, SD 57069, USAKathryn Solon - Division of Basic Biomedical Sciences, Laboratory of Neurological Sciences, The University of South Dakota, Sanford School of Medicine, Vermillion, SD 57069, USADavid W McNeal - Division of Basic Biomedical Sciences, Laboratory of Neurological Sciences, The University of South Dakota, Sanford School of Medicine, Vermillion, SD 57069, USAKimberly S Stilwell-Morecraft - Division of Basic Biomedical Sciences, Laboratory of Neurological Sciences, The University of South Dakota, Sanford School of Medicine, Vermillion, SD 57069, USARobert J Morecraft - Division of Basic Biomedical Sciences, Laboratory of Neurological Sciences, The University of South Dakota, Sanford School of Medicine, Vermillion, SD 57069, USA
- Resource Type
- Journal article
- Publication Details
- Experimental neurology, Vol.220(1), pp.90-108
- DOI
- 10.1016/j.expneurol.2009.07.034
- PMID
- 19679127
- PMCID
- PMC2778269
- NLM abbreviation
- Exp Neurol
- ISSN
- 0014-4886
- eISSN
- 1090-2430
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2009
- Academic Unit
- Anatomy and Cell Biology; Physical Therapy and Rehabilitation Science; Health, Sport, and Human Physiology
- Record Identifier
- 9984002481102771
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