Journal article
Volumetrics relate to the development of depression after traumatic brain injury
Behavioural brain research, Vol.271, pp.147-153
09/01/2014
DOI: 10.1016/j.bbr.2014.05.047
PMID: 24886777
Abstract
Previous research suggests that many people who sustain a traumatic brain injury (TBI), even of the mild form, will develop major depression (MD). We previously reported white matter integrity differences between those who did and did not develop MD after mild TBI. In this current paper, we aimed to investigate whether there were also volumetric differences between these groups, as suggested by previous volumetric studies in mild TBI populations. A sample of TBI-with-MD subjects (N = 14), TBI-without-MD subjects (N = 12), MD-without-TBI (N = 26) and control subjects (no TBI or MD, N = 23), received structural MRI brain scans. T1-weighted data were analysed using the Freesurfer software package which produces automated volumetric results. The findings of this study indicate that (1) TBI patients who develop MD have reduced volume in temporal, parietal and lingual regions compared to TBI patients who do not develop MD, and (2) MD patients with a history of TBI have decreased volume in the temporal region compared to those who had MD but without a history of TBI. We also found that more severe MD in those with TBI-with-MD significantly correlated with reduced volume in anterior cingulate, temporal lobe and insula. These findings suggest that volumetric reduction to specific regions, including parietal, temporal and occipital lobes, after a mild TBI may underlie the susceptibility of these patients developing major depression, in addition to altered white matter integrity. (C) 2014 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Volumetrics relate to the development of depression after traumatic brain injury
- Creators
- Jerome J. Maller - Monash Alfred Psychiatry Research centreRichard H. S. Thomson - Monash Alfred Psychiatry Research centreKerstin Pannek - Commonwealth Scientific and Industrial Research OrganisationNeil Bailey - Monash Alfred Psychiatry Research centrePhilip M. Lewis - The Alfred HospitalPaul B. Fitzgerald - Monash Alfred Psychiatry Research centre
- Resource Type
- Journal article
- Publication Details
- Behavioural brain research, Vol.271, pp.147-153
- DOI
- 10.1016/j.bbr.2014.05.047
- PMID
- 24886777
- NLM abbreviation
- Behav Brain Res
- ISSN
- 0166-4328
- eISSN
- 1872-7549
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- NHMRC Practitioner Fellowship; National Health & Medical Research Council (NHMRC) of Australia NHMRC Early Career Fellowship; National Health & Medical Research Council (NHMRC) of Australia Cervel Neurotech
- Language
- English
- Date published
- 09/01/2014
- Academic Unit
- Radiology
- Record Identifier
- 9984848509002771
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