Journal article
Voluntary Exercise Prevents Hypertensive Response Sensitization Induced by Angiotensin II
Frontiers in neuroscience, Vol.16, 848079
02/01/2022
DOI: 10.3389/fnins.2022.848079
PMCID: PMC8891537
PMID: 35250473
Abstract
Exercise training has profound effects on the renin-angiotensin system, inflammatory cytokines and oxidative stress, all of which affect autonomic nervous system activity and regulate blood pressure (BP) in both physiological and pathophysiological states. Using the Induction-Delay-Expression paradigm, our previous studies demonstrated that various challenges (stressors) during Induction resulted in hypertensive response sensitization (HTRS) during Expression. The present study tested whether voluntary exercise would protect against subpressor angiotensin (ANG) II-induced HTRS in rats. Adult male rats were given access to either “blocked” (sedentary rats) or functional running (exercise rats) wheels for 12 weeks, and the Induction-Delay-Expression paradigm was applied for the rats during the last 4 weeks. A subpressor dose of ANG II given during Induction produced an enhanced hypertensive response to a pressor dose of ANG II given during Expression in sedentary rats in comparison to sedentary animals that received saline (vehicle control) during Induction. Voluntary exercise did not attenuate the pressor dose of ANG II-induced hypertension but prevented the expression of HTRS seen in sedentary animals. Moreover, voluntary exercise reduced body weight gain and feed efficiency, abolished the augmented BP reduction after ganglionic blockade, reversed the increased mRNA expression of pro-hypertensive components, and upregulated mRNA expression of antihypertensive components in the lamina terminalis and hypothalamic paraventricular nucleus, two key brain nuclei involved in the control of sympathetic activity and BP regulation. These results indicate that exercise training plays a beneficial role in preventing HTRS and that this is associated with shifting the balance of the brain prohypertensive and antihypertensive pathways in favor of attenuated central activity driving sympathetic outflow and reduced BP.
Details
- Title: Subtitle
- Voluntary Exercise Prevents Hypertensive Response Sensitization Induced by Angiotensin II
- Creators
- Baojian Xue - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, United StatesJun-Ling Cui - Department of Neurosurgery, Second Hospital of Hebei Medical University, Shijiazhuang, ChinaFang Guo - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, United StatesTerry G. Beltz - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, United StatesZi-Gang Zhao - Institute of Microcirculation, Hebei North University, Zhangjiakou, ChinaGeng-Shen Zhang - Department of Neurosurgery, Second Hospital of Hebei Medical University, Shijiazhuang, ChinaAlan Kim Johnson - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- Frontiers in neuroscience, Vol.16, 848079
- DOI
- 10.3389/fnins.2022.848079
- PMID
- 35250473
- PMCID
- PMC8891537
- NLM abbreviation
- Front Neurosci
- eISSN
- 1662-453X
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 02/01/2022
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Neurology (Pediatrics); Health, Sport, and Human Physiology
- Record Identifier
- 9984221630202771
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