Journal article
Vulvar High-Grade Squamous Intraepithelial Lesions and Cancer as a Risk Factor for Anal Cancer: A Review
Journal of lower genital tract disease, Vol.26(1), pp.32-37
01/01/2022
DOI: 10.1097/LGT.0000000000000631
PMID: 34670242
Abstract
Anal squamous cell carcinoma (ASCC) has a higher incidence described in certain groups, namely, in women with vulvar high-grade squamous intraepithelial lesions (vHSILs) and/or human papillomavirus squamous cell carcinoma (VSCC). This review describes terminology, vHSIL, and VSCC in their association with ASCC and the published recommendations for early detection of this cancer in these women.
A narrative review was conducted by the authors on vHSIL and VSCC as risk factors for ASCC.
The ASCC and VSCC incidence are increasing. Women with vHSIL and/or VSCC can present with ASCC at diagnosis, being one of the highest-risk groups. Suspicious symptoms include rectal bleeding, pain, and a sensation of an anal mass. Digital anorectal examination can help detect early ASCC. Sensitivity of anal cytology in women with vHSIL and VSCC seems low, with the exception of immunosuppressed women with genital neoplasia (cervix, vagina, and vulva). There are still insufficient data on high-resolution anoscopy in women with vHSIL and/or VSCC as a screening method.
Clinicians need be aware that women with vHSIL and VSCC comprise one of the highest-risk groups for ASCC. Inquiring suggestive symptoms of ASCC and a digital anorectal examination can help in the early detection of this type of cancer.
Details
- Title: Subtitle
- Vulvar High-Grade Squamous Intraepithelial Lesions and Cancer as a Risk Factor for Anal Cancer: A Review
- Creators
- Andreia Albuquerque - Centre for Health Technology and Services ResearchColleen K Stockdale - University of IowaDebra Heller - Rutgers, The State University of New JerseyJacob Bornstein - Western Galilee HospitalJennifer M Roberts - Douglass Hanly Moir PathologyMario Preti - University of TurinI Mary Poynten - Kirby InstitutePedro Vieira-Baptista
- Resource Type
- Journal article
- Publication Details
- Journal of lower genital tract disease, Vol.26(1), pp.32-37
- DOI
- 10.1097/LGT.0000000000000631
- PMID
- 34670242
- ISSN
- 1526-0976
- eISSN
- 1526-0976
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984318225902771
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